Nevo O, Soustiel JF, Thaler I. Cerebral blood flow is increased during controlled ovarian stimulation. Am J Physiol Heart Circ Physiol 294: H3265–H3269, 2007. First published October 26, 2007; doi:10.1152/ajpheart.00633.2007.—Estrogen appears to enhance cerebral blood flow (CBF). An association between CBF and physiologically altered hormonal levels due to menstrual cycle, menopause, or exogeno...

Correct controlled ovarian stimulation is of paramount importance in assisted reproductive technologies. Therefore, analysis of the ovarian reserve of the patient is mandatory to tailor the best ovarian stimulation regimen. When the ovarian reserve is reduced, the induction of a multifollicular growth remains a challenge. Several factors could be associated with reduced ovarian response. Howeve...

Ovarian hyperstimulation syndrome (OHSS) is a serious and potentially life-threatening complication of controlled ovarian stimulation (COS). OHSS is an iatrogenic complication of ovulation induction, which may cause serious impact on patient’s health. OHSS is the most feared complication of IVF-related ovarian stimulation, which in its severe form leads to hospitalization and in the worst case ...

BACKGROUND Milder ovarian stimulation protocols for in vitro fertilization (IVF) are being developed to minimize adverse effects. Mild stimulation regimens result in a decreased number of oocytes at retrieval. After conventional ovarian stimulation for IVF, a low number of oocytes are believed to represent poor ovarian reserve resulting in reduced success rates. Recent studies suggest that a si...

BACKGROUND Polycystic ovarian syndrome (PCOS) is characterized by increased ovarian angiogenesis and vascularity. Accumulating evidence indicates that vascular endothelial growth factor (VEGF) is increased in PCOS and may play an important role in these vascular changes and the pathogenesis of this disease. Placental growth factor (PlGF), a VEGF family member, has not been previously characteri...

Adverse drug reactions (ADRs) are a major problem in drug therapy and drug development. Inter-individual genetic differences can have significant roles in determining an individual’s susceptibility to ADRs. The rapid development of techniques in the area of genome analysis has put the scientific community in a power position and facilitated identification of new pharmacogenomic biomarkers that ...

Successful IVF/ICSI treatment depends on obtaining a sufficient oocyte sample and selecting patients carefully. COH (Controlled Overian Hyperstimulation) treatment in patients with poor ovarian response is one of the most important issues in IVF programmes. The ovarian response that follows ovarian stimulation is the most important determiner in ART treatment. Although many other stimulation pr...

background: controlled ovarian hyper stimulation coh/iui represents a therapy applicable to a wide variety of infertility diagnosis with no significant mechanical distortion of pelvic viscera. identified variables influenced in intra uterine insemination include: age, cause of infertility, sperm number, motility and normal percentage, use of gonadotropine and number of attempts at iui. the role...

The role of follicle stimulating hormone (FSH) in assisted repro­ ductive technology is well understood, though there is still no published consensus on the need for exogenous luteinizing hormone (LH) in controlled ovarian stimulation. There is a dilemma regarding the usefulness of LH supplementation in controlled ovarian stimulation despite growing understanding of the LH and FSH interrelation...