Objective(s) The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of theophylline using ethylcellulose as the retardant material with high entrapment efficiency. Materials and Methods Microspheres were prepared by water-in-oil-in-oil (W/O1/O2) emulsion-solvent diffusion (ESD). A mixed solvent system consisting of acetonitrile and dichloromet...

modification of the mechanical properties of silicone rubber were considered for drug delivery systems by using high-energy electron beam (e-beam). in this research work, two different medical grades of silicone rubbers were used to prepare matrices containing 10wt% progesterone with 2 mm thickness and irradiated with e-beam at dose range of 25 up to 200 kgy. then, the mechanical properties as ...

the aim of this study is to formulate a novel ophthalmic nanosuspension (ons), an alternative carrier system to traditional colloidal carriers for controlled release (cr) of acyclovir (acv). in the present study, ons is employed to avoid some of major disadvantages of colloidal carriers systems such as instability in cul de sac and short half life by increasing efficiency of drug encapsulation ...

This paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). Tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...

The aggregation of personal attributes into user profiles is a significant privacy concern. Existing attribute management systems support the controlled release of attributes and unlinkability between session protocols, but do not address the problem that attributes distributed in this way may be data-mined for features that allow user profiles to be reconstructed. This paper identifies the agg...

the objective of this work was to develop and evaluate the levofloxacin hemihydrate floating formulations (f1-f9). selection of optimized batch was done by model dependent approach and novel mathematical approach. f1-f9 batches were prepared by direct compression method using gelucire 43/01 (hydrophobic) and hydroxypropylmethylcellulose (hydrophilic) polymer in different ratios. the floating ta...

Hydrogel Based Metronidazole Bioadhesive Tablet (HMBT) was prepared as a novel vaginal delivery system to achieve Controlled release of drug from the tablet for vaginal candidiasis. The highly swollen hydrogel were prepared by dissolving chitosan in acetic acid solution containing drug, followed by neutralisation with sodium hydroxide and characterized by SEM, DSC and FT-IR and evaluated for % ...