نتایج جستجو برای: cooperativity
تعداد نتایج: 4692 فیلتر نتایج به سال:
Cavity quantum electrodynamics (QED) with cooperativity far greater than unity enables high-fidelity sensing and information processing. The high-cooperativity regime is often reached through the use of short single-mode resonators. More complicated multimode resonators, such as near-confocal optical Fabry-Prot cavity, can provide intracavity atomic imaging in addition to high cooperativity. Th...
This combination of phenomenological and mechanistic modeling unveils key conditions for simultaneous initiation bacterial DNA replication at multiple origins, emphasizing the high level molecular cooperativity required to achieve remarkable synchronization observed in experiments.
This study investigated the reciprocal cross-interactions between two distinct allosteric sites on the M(4) muscarinic acetylcholine receptor (mAChR) in the absence or presence of different orthosteric ligands. Initial studies revealed that two novel benzimidazole allosteric modulators, 17-beta-hydroxy-17-alpha-ethy nyl-delta(4)-androstano[3,2-b]pyrimido[1,2-a]benzimidazole (WIN 62,577) and 17-...
The cytochrome P450s (CYPs) are the major enzymatic detoxification and drug metabolism system. Recently, it has become clear that several CYP isoforms exhibit positive and negative homotropic cooperativity. However, the toxicological implications of allosteric kinetics have not been considered, nor understood. The allosteric kinetics are particularly enigmatic in several respects. In many cases...
The hydrophobic interaction drives nonpolar solutes to aggregate in aqueous solution, and hence plays a critical role in many fundamental processes in nature. An important property intrinsic to hydrophobic interaction is its cooperative nature, which is originated from the collective motions of water hydrogen bond networks surrounding hydrophobic solutes. This property is widely believed to enh...
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