We have developed a highly effective copper-catalyzed decarboxylative coupling of alkynylcarboxylic acids with various aryl and alkyl halides at 2 mol% loading of copper. This method is simple, economical and practical for the synthesis of disubstituted alkyne compounds.

The continuous rise of multi-drug resistant pathogenic bacteria has become a significant challenge for the health care system. In particular, novel drugs to treat infections of methicillin-resistant Staphylococcus aureus strains (MRSA) are needed, but traditional drug discovery campaigns have largely failed to deliver clinically suitable antibiotics. More than simply new drugs, new drug discove...

Copper-based compounds are some of the most important biocides for the protection of wood in heavy duty applications. In the past, copper was combined with chromium compounds to reduce copper leaching, but a recent generation of copper-based preservatives uses ethanolamine as a fixative. To elucidate the leaching of copper biocides from wood, Norway spruce (Picea abies) wood was treated with a ...

Blue copper proteins (Type I) exhibit unusual spectral and chemical properties such as higher reduction potentials and small hyperfine coupling constants A|| in the EPR spectrum in comparison with other copper(II) complexes. Such unusual properties are justified partly by the tetralhedral geometry around the copper(II) site and partly by the CuN2S2 chromophores in which the soft S atoms coordin...

Newly synthesized phthalazine derivatives including copper and platinum complexes were evaluated for cytotoxicity in human breast cancer cell lines. The cells were incubated with the compounds (100 microM) for 72 h and cytotoxicity, apoptosis and DNA content were measured by flow cytometery. Our results suggest that the parent (H1-2), copper (C1-2)- and platinum (P1-2)-derivatized compounds wer...

Copper (II) complexes of three phosphonate ligands were prepared and fully characterized by elemental analysis, spectral and thermal studies. The IR spectral data showed that the phosphonate compounds behave as bidentate ligands coordinating to the copper ion through the P=O and NH groups. The electronic spectroscopic data support a distorted octahedral geometry around copper ion. The activity ...

To explain the unusually high selectivity of copper catalysts toward linolenate, model compounds were hydrogenated (150 C and atmospheric pressure) and the reaction products analyzed. Products varied depending upon location of the double bonds. Monoenes were not reduced by copper chromite except when the double bond was next to a carboxyl group. Dienes with isolated double bonds also were not r...

1. Copper compounds (calcium copper edetate, copper heptanoate, copper methionate, copper chloride, copper oxide, dicopper oxide and copper gluconate) are normally used, orally in feed or in an injectable solution, to treat copper deficiency in food-producing animals. In veterinary medicine, the recommended doses are 50 to 100 mg copper per animal given as a single injection. Copper has antimic...

Benthic fluxes of copper, copper complexing ligands and thiol compounds in the shallow waters of Venice Lagoon (Italy) were determined using benthic chambers and compared to porewater concentrations to confirm their origin. Benthic copper fluxes were small due to small concentration differences between the porewaters and the overlying water, and the equilibrium concentration was the same at bot...

Bivalent copper and the Schiff's base pyridylalpydidylhydrazine form two compounds, composed respectively of one molecule and of two molecules of the organic compound to one atom of copper, and having ultra violet absorption spectra differing only in the value of the molar extinction coefficients at the absorption maxima, 15,100 and 22,450, respectively at 345 mμ. The respective formation const...