Two dinuclear copper(II) thioether-oxime complexes ([Cu(DtdoH)]2(ClO4)2 and [Cu(DtudH)]2(ClO4)2 Æ 2CH3OH) have been synthesized. [Cu(DtdoH)]2(ClO4)2 reacted with excess BF3 Æ OEt2 to yield [Cu(Thyclops)]ClO4, a BF2 þ-macrocyclized di-oxime. [Cu(DtdoH)]2(ClO4)2 and [Cu(DtudH)]2(ClO4)2 Æ 2CH3OH are the first representatives of copper(II) thioether oximes which exhibit the classical out-of-plane o...

Speciation of copper in the electrokinetic treatments of an industrial sludge was studied by in situ extended X-ray absorption fine structural (EXAFS) and X-ray absorption near-edge structural (XANES) spectroscopies in the present work. The least-square fits (LSF) of the XANES spectra indicated that the main copper species in the sludge were Cu(NO)(3) (82%) and adsorbed copper (Cu/SiO(2)) (17%)...

Integral and angle resolved thermal desorption spectroscopies were used to study methanol adsorption and oxidation on clean and oxygen covered Cu(110) surfaces. Special emphasis was put on the Cu-CuO stripe phase, which forms when the Cu(110) surface is covered with 0.25 ML of oxygen. In the temperature regime between 200 and 300 K associative desorption of methanol and water takes place, showi...

Naturally fauna-free crossbred rams approximately 5 mo old, 49.3 +/- 1.88 kg live weight, were allotted to four groups. Two groups remained fauna-free, whereas the other two groups were faunated. A diet based on corn silage-soybean meal containing either a low or a high Cu concentration (7 or 15 micrograms/g dry matter) was fed ad libitum to the two groups for 197 d. The rams were killed at the...

Copper (Cu) is a required micronutrient, but it is highly toxic at high concentrations. Therefore, the levels of Cu must be tightly regulated in all living cells. The phagosome of Mycobacterium tuberculosis has been shown to have variable levels of Cu. Previously, we showed that M. tuberculosis contains a copper-sensitive operon, cso, that is induced during early infection in mice. In this stud...

Copper transporting ATPase, ATP7A, is an ATP dependent copper pump present in all vertebrates, critical for the maintenance of intracellular and whole body copper homeostasis. Effects of copper treatment on ATP7A gene expression in fibroblast cells (SAF1) of the sea bream (Sparus aurata) were investigated by qRT-PCR and by a medium density microarray from a closely related species, striped sea ...

Twenty-eight Brangus cattle were used to determine the effect of copper and selenium supplementation on performance, feed efficiency, composition of fatty acids in Longissimus dorsi (LD) muscle, and cholesterol concentration in serum and in LD muscle and enzymes activities, reduced glutathione (GSH) and oxidized glutathione (GSSG). The treatments were: i) Control, without copper (Cu) and seleni...

Menkes disease (MD) is a neurodegenerative disorder characterized by copper deficiency. It is caused by defective intestinal absorption of copper resulting from a deficiency of a copper-transporting ATPase, ATP7A. We investigated the effects of combination therapy with copper and disulfiram, a known lipophilic chelator. We synthesized a copper-disulfiram complex (Cu-DSF) and determined its crys...

Glass is a freezing phase of a deeply supercooled liquid. Despite its simple definition, the origin of glass forming ability (GFA) is still ambiguous, even for binary Cu-Zr alloys. Here, we directly study the stability of the supercooled Cu-Zr liquids where we find that Cu64Zr36 at a supercooled temperature shows deeper undercoolability and longer persistence than other neighbouring composition...

UNLABELLED Copper is an essential micronutrient used as a metal cofactor by a variety of enzymes, including cytochrome c oxidase (Cox). In all organisms from bacteria to humans, cellular availability and insertion of copper into target proteins are tightly controlled due to its toxicity. The major subunit of Cox contains a copper atom that is required for its catalytic activity. Previously, we ...