نتایج جستجو برای: cord blood expansion

تعداد نتایج: 887905  

2017
Howard R. Seay Amy L. Putnam Judit Cserny Amanda L. Posgai Emma H. Rosenau John R. Wingard Kate F. Girard Morey Kraus Angela P. Lares Heather L. Brown Katherine S. Brown Kristi T. Balavage Leeana D. Peters Ashley N. Bushdorf Mark A. Atkinson Jeffrey A. Bluestone Michael J. Haller Todd M. Brusko

Umbilical cord blood is a traditional and convenient source of cells for hematopoietic stem cell transplantation. Thymic regulatory T cells (Tregs) are also present in cord blood, and there is growing interest in the use of autologous Tregs to provide a low-risk, fully human leukocyte antigen (HLA)-matched cell product for treating autoimmune diseases, such as type 1 diabetes. Here, we describe...

Journal: :Blood 2013
Karen K Ballen Eliane Gluckman Hal E Broxmeyer

Umbilical cord blood is an alternative hematopoietic stem cell source for patients with hematologic diseases who can be cured by allogeneic hematopoietic cell transplantation. Initially, umbilical cord blood transplantation was limited to children, given the low cell dose infused. Both related and unrelated cord blood transplants have been performed with high rates of success for a variety of h...

Journal: :Iranian journal of immunology : IJI 2017
Monireh Zare Behnaz Valipour Seyede Momeneh Mohammadi Mohammad Nouri Aliakbar Movassaghpour Hojjatollah Nozad Charoudeh

BACKGROUND The mammalian target of rapamycin (mTOR) is important in hematopoiesis. Despite the central role of mTOR in regulating the differentiation of immune cells, the effect of mTOR function on cord blood mononuclear cells is yet to be defined. OBJECTIVES To evaluate the effect of mTOR inhibition, using rapamycin on the proliferation and apoptosis of cord blood mononuclear cells, as well ...

Journal: :cell journal 0

introduction: umbilical cord blood is a rich source of hematopoietic cells and can be used in the clinical setting for hematopoietic cell transplantation in graft versus host disease (gvhd). a number of different drugs have been used as prophylaxis against gvhd including corticosteroids, cyclosporine a (cy a) and fk506. in this study, the in vitro effects of fk506 on cord blood mononuclear cell...

Journal: :Biology of Blood and Marrow Transplantation 2013

Journal: :Best Practice & Research Clinical Haematology 2011

Journal: :Journal of Blood Disorders & Transfusion 2013

2011
Katsuhiro Kita Jong O. Lee Celeste C. Finnerty David N. Herndon

Umbilical cord blood has served as an alternative to bone marrow for hematopoietic transplantation since the late 1980s. Numerous clinical studies have proven the efficacy of umbilical cord blood. Moreover, the possible immaturity of cells in umbilical cord blood gives more options to recipients with HLA mismatch and allows for the use of umbilical cord blood from unrelated donors. However, mor...

Journal: :novelty in biomedicine 0
mehdi azad department of medical laboratory sciences, faculty of allied medicine, qazvin university of medical sciences, qazvin, iran mehdi goudarzi department of microbiology, school of medicine, shahid beheshti university of medical science, tehran, iran ali dehghanifard sarem cell research center, sarem women’s hospital, tehran, iran mousa vatanmakanian department of hematology, allied medical school, tehran university of medical sciences, tehran, iran mehdi sahmani department of clinical biochemistry and genetics, cellular and molecular research centre, qazvin university of medical sciences, qazvin, iran

background: vast variety of intermediate factors including cell cycle regulators, growth factors, transcription factors, and signaling pathways are involved in hematopoietic stem cell (hsc) commitment and differentiation into distinct lineages. vhl, ecad, and runx3 are among these. epigenetics is currently introduced as a potential mechanism to control the gene regulation. the aim of this study...

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