Bevirimat [BVM, PA-457, 3-O-(3',3'-dimethylsuccinyl)-betulinic acid], a new anti-human immunodeficiency virus drug candidate, is metabolized to two monoglucuronides [mono-BVMG (I) and mono-BVMG (II)] and one diglucuronide (di-BVMG) both in vivo and in vitro. UDP-glucuronosyltransferase (UGT) reaction screening, enzyme kinetics, and species differences for the glucuronidation of BVM in vitro wer...

This document provides a solution to prevent the FPGA designs from being copied. It allows the FPGA design to remain secure even if the configuration bitstream is captured. This is accomplished by disabling the functionality of the user design within the FPGA until handshaking tokens are passed to the FPGA from the MAX ® II device. The MAX II devices are selected for generating the handshaking ...

In this paper we study the evolution of core and corona of nine open clusters using the projected radial density profiles derived from homogeneous CCD photometric data obtained through the 105-cm Kiso Schmidt telescope. The age and galactocentric distance of the target clusters varies from 16 Myr to 2000 Myr and 9 kpc to 10.8 kpc respectively. Barring Be 62, which is young open cluster, other c...

A set S ⊆ V is independent in a graph G = (V, E) if no two vertices from S are adjacent. The independence number α(G) is the cardinality of a maximum independent set, while μ(G) is the size of a maximum matching in G. If α(G) + μ(G) = |V |, then G is called a König-Egerváry graph. The number dc (G) = max{|A| − |N (A)| : A ⊆ V } is called the critical difference of G [21], where N (A) = {v : v ∈...

Background and Aim: The conventional procedure for removal of porcelain laminate veneers (PLVs) is time-consuming and inconvenient. The purpose of this study was to evaluate the efficacy of Er:YAG laser for debonding of PLVs. Materials and Methods: Forty-eight intact extracted human maxillary anterior teeth received discoid PLVs (24 feldspathic and 24 e-max ceramic). The PLVs had 0.7 mm thickn...

OBJECTIVES The aim of the present investigation was to study the influence of a reduced bone support on the fracture resistance of endodontically treated teeth restored with glass fibre-reinforced posts (FRC). METHODS 30 caries-free maxillary central incisors were divided into 3 groups (n=10). Endodontic treatment was performed. Teeth were flattened 2 mm above the cemento-enamel junction. Gro...

We construct the first constant time value approximation schemes (CTASs) for Metric and Quasi-Metric MAX-rCSP problems for any r ≥ 2 in a preprocessed metric model of computation, improving over the previous results of [FKKV05] proven for the general core-dense MAX-rCSP problems. They entail also the first sublinear approximation schemes for constructing approximate solutions of the above optim...

Telomerase activation is thought to be a critical step in cellular immortalization and carcinogenesis. The human telomerase catalytic subunit (hTERT) is a rate limiting determinant of the enzymatic activity of human telomerase. In the previous study, we identified the proximal 181 bp core promoter responsible for transcriptional activity of the hTERT gene. To identify the regulatory factors of ...