Corneal Pathologic Responses The normal cornea is clear, and any alteration in clarity signifies pathology. Pathologic changes include corneal vessels, edema, pigment, crystalline deposits, inflammatory cell infiltrates, destruction from degradative enzymes, and scarring. Such changes are usually non-specific and incited by numerous causes. Pathologic responses can occur singularly, but more of...

PURPOSE To report the adverse event of topical tosufloxacin administered after penetrating keratoplasty in one patient. CASE REPORT A 60-year-old female was referred to our hospital for treatment of vision loss due to corneal opacification, etiology was unknown. Slit lamp examination showed dense opacification in corneal stroma. Penetrating keratoplasty was performed on her left eye. She was ...

Diabetes Mellitus is most commonly manifested as fast developing cataracts. This type of cataract is the result of increased glucose in the aqueous humor. The cataract often has a prominent Y suture line on the anterior portion of the lens, making it the “Yes” for diabetes. Blood glucose is recommended for diagnosis. In fact 85% of all diabetic dogs will develop cataracts within 18 months of di...

Objective: To study ocular manifestations in patients who were on long-term use of chlorpromazine. Methods: A retrospective observational case study was made. Three patients, who were diagnosed as Schizophrenia and on long-term use of chlorpromazine for more than 20 years, were examined retrospectively. The examinations included clinical history, physical examination, slit-lamp biomicroscopy, a...

Purpose. To evaluate the confocal microscopy findings of a 46-year-old male with bilateral biopsy proven argyrosis. Materials and Methods. Besides routine ophthalmologic examination, anterior segment photography and confocal microscopy with cornea Rostoch module attached to HRT II (Heidelberg Engineering GmbH, Heidelberg, Germany) were performed. Findings. Squamous metaplastic changes on conjun...

Mutations in keratoepithelin are associated with blinding ocular diseases, including lattice corneal dystrophy type 1 and granular corneal dystrophy type 2. These diseases are characterized by deposits of amyloid fibrils and/or granular non-amyloid aggregates in the cornea. Removing the deposits in the cornea is important for treatment. Previously, we reported the destruction of amyloid fibrils...

BACKGROUND Reis-Bücklers corneal dystrophy (RBCD) was consistently reported as a corneal dystrophy only affected Bowman's layer and superficial corneal stroma, and superficial keratectomy was a recommendation surgery for treatment in literatures. The study reported new histopathological and ultrastructural findings in RBCD caused by the Arg124Leu mutation of transforming growth factor induced (...

PURPOSE To analyze genotype-phenotype correlation in patients originating from Polish population with the transforming growth factor beta induced (TGFBI) corneal dystrophies. METHODS Sixty affected and 31 unaffected individuals from 15 unrelated Polish families were included in the study. The clinical diagnosis was based on the slit-lamp exam, 1310 nm time domain and 1310 nm swept source spec...

PURPOSE To report the clinicopathological findings of a Chinese patient with an unusual phenotype of gelatinous drop-like corneal dystrophy (GDLD) combined with spheroidal degeneration and to detect molecular defect in the tumor-associated calcium signal transducer 2 (TACSTD2) gene. METHODS Extensive physical and ophthalmologic examination of the patient was performed. Initially superficial k...