OBJECTIVE Corneal collagen cross-linking with riboflavin and UV-A (CXL) decreases corneal oedema and increases visual acuity in human patients with bullous keratopathy. Presumed mechanisms are an increase in collagen packing density and a reduction in stromal swelling pressure. We present two cases in which CXL was used to treat bullous keratopathy in dogs. PROCEDURES Four eyes of two dogs wi...

Integrin α6β4 is an integral membrane protein within hemidesmosomes and it mediates adhesion of epithelial cells to their underlying basement membrane. During wound healing, disassembly of hemidesmosomes must occur for sheet movement-mediated cell migration. The mechanisms of disassembly and reassembly of hemidesmosomes are not fully understood. The current study was initiated to understand the...

The recurrent epithelial erosion syndrome of the cornea is a common disorder; it usually follows specific trauma to the cornea, though it may present without such a history. It may sometimes be inherited or may occur in association with inherited corneal dystrophies (Duke-Elder and Leigh, I965; Griffith and Fine, I967). Clinically, the patient presents with symptoms of a sharp pain on opening t...

PURPOSE To describe the clinical stages and management of Achromobacter xylosoxidans keratitis with post-LASIK epithelial ingrowth in two patients. METHODS Retrospective chart review. RESULTS Both patients had been treated with topical antibiotics and corticosteroids for several weeks prior to presentation. Examination at presentation revealed significant areas of epithelial ingrowth withou...

PURPOSE A large Turkish family with 52 members, 26 of whom had Groenouw type 1 corneal granular dystrophy was evaluated by genetic linkage studies and mutation analyses. Phenotype- genotype correlations were also assessed. METHODS DNA from peripheral blood lymphocytes of 22 family members was used in establishing linkage to chromosome 5q31. Single-strand conformation polymorphism analysis was...

In patients with nephropathic cystinosis, corneal crystals develop by one year of age; they progressively accumulate and eventually cause recurrent corneal erosions and photophobia. After an in vitro study of cystinotic corneal stromal cells showed cystine depletion by cysteamine and after topical cysteamine was determined to be nontoxic in rabbits, we performed a controlled double-blind clinic...

On initial examination, the patient was found to have a right preauricular skin appendage, visual acuity of light perception in both eyes, a small right eye temporal limbal dermoid, and a right upper eyelid coloboma that involved approximately 70%–80% of the upper eyelid. There was near total exposure of the right corneal surface, with trace inferior punctate epithelial erosions but no epitheli...

Cover illustration: Coat of arms and location of the two Swedish counties Småland (lat. Smolandia) and Hälsingland (lat. Helsingia or Helsinglandia) wherefrom the two corneal disorders described in this thesis originate. Published articles and figures have been reprinted with the permission of the copyright holders. To my family and in memory of my father Turmoil accompanies every great change....

PURPOSE To evaluate the clinical features and outcomes of patients with recurrent corneal erosion syndrome who underwent anterior stromal puncture. STUDY DESIGN Retrospective, nonrandomized, consecutive case series. METHODS Database search of patients from 2003-2013 who underwent anterior stromal puncture was conducted at a tertiary care hospital cornea clinic. Charts of 30 patients (35 eye...