ABSTRACT Purpose: To evaluate the corneal and anterior chamber morphology in phakic eyes with noninfectious intraocular inflammation. Methods: This study included 59 active uveitis, 62 inactive 95 healthy eyes. Corneal endothelial cell density, hexagonal ratio, coefficient of variation (CV), thickness volume, maximum keratometry, volume depth (ACD) measurements were performed using a specular m...

We use a population balance model to study the mechanism and the rate of centripetal migration of epithelial cells, renewal of the corneal epithelial population by the cell derived from (progeny of) the limbal stem cells and the kinetics of the replacement of the donor corneal epithelium. The epithelial mass is constant under the normal circumstances and therefore the rate of cellular entry due...

PURPOSE Tonometry is widely used as the main screening tool supporting glaucoma diagnosis. Still, its accuracy could be improved if full knowledge about the variation of the corneal biomechanical properties was available. In this study, Optical Coherence Tomography (OCT) speckle statistics are used to infer the organisation of the corneal micro-structure and hence, to analyse its influence on i...

BACKGROUND We evaluated the relationships between corneal biomechanical properties and structural parameters in patients with newly diagnosed, untreated normal-tension glaucoma (NTG). METHODS All subjects were evaluated using an Ocular Response Analyzer (ORA) measuring corneal hysteresis (CH) and the corneal resistance factor (CRF). Central corneal thickness (CCT), Goldmann applanation tonome...

PURPOSE To investigate changes in the morphology of the corneal stroma after collagen cross-linking (CXL) treatment in bovine and porcine eyes using a nonlinear microscope providing both two-photon excitation fluorescence (TPEF) and second harmonic generation (SHG) corneal images. METHODS Freshly enucleated eyes were imaged using a tomographic nonlinear imaging method that was highly suitable...

Blood concentrations of ICI 35 868 have been determined in rat, pig, rabbit and cat after single i.v. injections. In all species the initial distribution volume was greater than blood volume and the overall distribution volume was large. Half-lives of the distribution phase were extremely short (1-6 min) and the terminal half-lives were also short (16-55 min). In all species examined a correlat...

BACKGROUND Ionic dialysance was recently introduced as a means to assess Kt/V (K(ID)t/V). With this method, urea distribution volume (V) has to be estimated. The primary aim of the present study was to assess the agreement between equilibrated Kt/V assessed by urea kinetic modelling (eKt/V) with K(ID)t/V taking into account different estimates of V, and to assess the monthly variation in V. Sec...