The craniosynostoses, the premature closure of the cranial sutures, are a common heterogeneous group of disorders, affecting about 1 in 2000 children at birth. About 20% have a distinct syndrome defined on clinical and family grounds. The delineation of these syndromes has become more precise with molecular analysis. Mutations in the fibroblast growth factor receptor 1, 2, 3 loci have been iden...

Introduction: The Crouzon syndrome is a rare clinical condition that affects the craniofacial skeleton development. It accounts for about 4.8% of all the cases of craniosynostosis, and it is the most common syndrome presenting with craniosynostoses. The Crouzon syndrome’s early diagnosis is critical to avoid cranial hypertension as well as visual disturbances and blindness. Children who have Cr...

Abstract Introduction Apert syndrome is an autosomal dominant malformation syndrome, accounting for 4.5% of all craniosynostoses. Raised intracranial pressure (ICP) in has a multifactorial aetiology, with incidence up to 45% if left untreated [1, 2]. ICP can be determined clinically, non-invasive and invasive methods. In this study, we want assess whether the use CT scans reliable identifying c...

The formation of cranial bone requires the differentiation of osteoblasts from undifferentiated mesenchymal cells. The balance between osteoblast recruitment, proliferation, differentiation and apoptosis in sutures between cranial bones is essential for calvarial bone formation. The mechanisms that control human osteoblasts during normal calvarial bone formation and premature suture ossificatio...

BACKGROUND Craniosynostosis is the premature fusion of cranial vault sutures. The overall incidence is 3-5/10,000 live births. With multiple craniosynostoses, brain growth may be impeded by the unyielding skull. Most cases of single suture involvement can be treated with linear excision of suture. Involvement of multiple sutures or skull has usually required combined efforts of neurosurgeons an...

BACKGROUND Craniosynostosis, the premature fusion of 1 or more sutures of the skull, is a common congenital defect, with a prevalence of 1 in 2500 live births. Untreated progressive craniosynostosis leads to inhibition of brain growth and increased intracranial and intraorbital pressure. The heterogeneity of clinical phenotypes and the overlap of the various associated syndromes render the corr...

The term "craniofacial anomalies" (CFAs) refers to a diverse group of congenital disorders including complex syndromes marked by multiple sutural fusions (e.g., Crouzan's, Treacher Collins, and Aperts syndromes), simple craniosynostoses involving single fusions (e.g., sagittal synostosis), hemifacial microsomia, clefts of the lip and/or palate, and isolated "birth marks" on the face and neck, s...

Introduction: Crouzon syndrome (CS), the most common craniosynostosis condition, which could lead to several developmental complications. This study aimed review different manifestations of CS. Material and Methods: In order find relevant articles, databases PubMed, Scopus, Web Science, Cochrane Library were searched using term “Craniofacial Dysostosis” its entry terms. All English-language art...