In the testicular compartment, cAMP response element binding protein (CREB) and cAMP response element modulator (CREM) transcription factors are important transducers of hormonal signals into the induction of gene expression. Selenium (Se) is essential for male fertility. It has been shown earlier in our lab that selenite modulates Nuclear Factor κB, Activator Protein-1 and Stress Activated Pro...

Impulsivity, a multifaceted behavioral hallmark of attention-deficit/hyperactivity disorder (ADHD), strongly influences addiction vulnerability and other psychiatric disorders that incur enormous medical and societal burdens yet the neurobiological underpinnings linking impulsivity to disease remain poorly understood. Here we report the critical role of ventral striatal cAMP-response element mo...

Camp-Responsive Element Modulator (CREM) is a key factor in the regulation of the expression of number of post-meiotic genes during spermatogenesis. Matricaria recutita shows different pharmacological activities like anti-inflammatory, anti-cancer, treatment of stress and depression, anti-allergic and etc. The objectives of this study are to investigate effects of Matricaria recutita on spermat...

Using next-generation, transcriptome-wide RNA sequencing (RNA-Seq) technology we assessed the effects of exercise training on transcriptional profiles in skeletal muscle arterioles isolated from the soleus and gastrocnemius muscles of Otsuka Long Evans Tokushima Fatty (OLETF) rats that underwent an endurance exercise training program (EX; n = 13), interval sprint training program (SPRINT; n = 1...

Although CREB seems to be important for memory formation, it is not known which of the isoforms of CREB, CREM, or ATF1 are expressed in the neurons that undergo long-term synaptic changes and what roles they have in memory formation. We have found a single Aplysia CREB1 gene homologous to both mammalian CREB and CREM and have characterized in the sensory neurons that mediate gill-withdrawal ref...

47 Using next generation, transcriptome-wide, RNA sequencing (RNA-Seq) technology we 48 assessed the effects of exercise training on transcriptional profiles in skeletal muscle arterioles 49 isolated from the soleus and gastrocnemius muscles of Otsuka Long Evans Tokushima Fatty 50 (OLETF) rats that underwent an endurance exercise training program (EX; n=13), interval sprint 51 training program ...

Transcriptional repression is a fundamental mechanism of gene regulation. cAMP response element (CRE) modulator (CREM)alpha is an ubiquitously expressed transcription factor and a counterpart of the activator CREB. In T cells, CREM is responsible for the termination of the IL-2 expression by a chromatin-dependent mechanism. We demonstrate in this study that CREMalpha associates with histone dea...

Alternative splicing of CREB (cAMP response element binding protein) and CREM (cAMP response element modulator) mRNAs in separated pachytene spermatocyte, round spermatid, and elongated spermatid fractions and the germ cell-derived immortalized cell line GC-2spd(ts) was studied by reverse transcription polymerase chain reaction (RT-PCR). Both primary germ cells and the GC-2spd(ts) cell line exp...

The skin-sensitizing potential of chemicals is an important concern for public health and thus a significant end point in the hazard identification process. To determine skin-sensitizing capacity, large research efforts focus on the development of assays, which do not require animals. As such, an in vitro test has previously been developed based on the differential expression of CREM and CCR2 t...

background: alpinia galanga (a. galanga) belongs to the zingiberaceae family has anti-oxidant effects in animals and humans body and often is used as medicament or part of medicaments in asian folk medicine for various applications. objective: the objective of this study was to investigate the molecular and biochemical influence of alcoholic extract from the rhizomes of a. galangal on the sperm...