Experimental studies on astrophysical reactions involving radioactive isotopes (RI) often accompany technical challenges. Studies such nuclear have been conducted at the low-energy RI beam separator CRIB, operated by Center for Nuclear Study, University of Tokyo. We discuss two cases reaction CRIB; one is 7 Be+ n which may affect primordial Li abundance in Big-Bang nucleosynthesis, and other 22...

AIM To investigate the feasibility of developing an objective tool for predicting death and severe disability using routinely available data, including an objective measure of illness severity, in very low birthweight babies. METHOD A cohort study of 297 premature babies surviving the first three days of life was made. Predictive variables considered included birthweight, gestation, 3 day cra...

The Saccharomyces cerevisiae kinase Ste20 is a member of the p21-activated kinase (PAK) family with several functions, including pheromone-responsive signal transduction. While PAKs are usually activated by small G proteins and Ste20 binds Cdc42, the role of Cdc42-Ste20 binding has been controversial, largely because Ste20 lacking its entire Cdc42-binding (CRIB) domain retains kinase activity a...

INTRODUCTION The purpose of this study was to evaluate the long-term stability of quad-helix/crib treatment in subjects with dentoskeletal open bite. METHODS Twenty-eight subjects (11 boys, 17 girls; mean age, 8.2 ± 1.3 years) were treated consecutively with quad-helix/crib appliances. The patients were reevaluated at the end of active treatment with the quad-helix/crib (mean age, 9.7 ± 1.6 y...

family of CRIB domain–containing proteins is represented by the nonreceptor tyrosine kinases ACK-1 (Manser et al., 1993) and ACK-2 (Yang et al., 1997), which are highly specific targets for Cdc42. While these tyrosine kinases have yet to be linked to a specific pathological condition, it is likely that they will play important roles in neuronal cell function as they are highly expressed in brai...

Cdc42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization, kinase-signaling activation, and cell polarization. MSE55 is a nonkinase CRIB (Cdc42/Rac interactive-binding) domain-containing molecule of unknown function. Using glutathione S-transferase-capture experiments, we show that MSE55 binds to Cdc42 in a GTP-dependent manner. MSE55...

OBJECTIVES To evaluate and compare birthweight and scores as predictors of neonatal mortality in a Neonatal Intensive Care Unit (NICU). METHODS The survey included 494 newborns admitted to the neonatal intensive care unit (NICU) of a general hospital in Porto Alegre, southern Brazil, immediately after delivery, between March 1997 and June 1998. Birthweight and scores were evaluated in terms o...