PRINCIPLES OF VALIDATION OF DIAGNOSTIC ASSAYS FOR INFECTIOUS DISEASES. Assay validation requires a series of inter-related processes. Assay validation is an experimental process: reagents and protocols are optimized by experimentation to detect the analyte with accuracy and precision. Assay validation is a relative process: its diagnostic sensitivity and diagnostic specificity are calculated re...

Reversal learning deficits following reward and punishment processing are observed across disruptive behaviors (DB) attention-deficit/hyperactivity disorder (ADHD), have been associated with callous-unemotional (CU) traits. However, it remains unknown to what extent these altered reinforcement sensitivities linked the co-occurrence of oppositional traits, ADHD symptoms, CU Reward sensitivity pe...