نتایج جستجو برای: crossover trial
تعداد نتایج: 343534 فیلتر نتایج به سال:
BACKGROUND To assess the influence of therapy crossovers on treatment comparisons and mortality at 5 years in patients with ischemic heart disease and heart failure randomly assigned to medical therapy alone (MED) or to MED and coronary artery bypass graft (CABG) surgery in the Surgical Treatment for Ischemic Heart Failure (STICH) trial. METHODS AND RESULTS The influence of early crossover (w...
background & aim: case-crossover studies are the case-control version of crossover studies. in these studies, cases and controls are the same subjects. the term crossover is applied for designs that all subjects pass through both treatment (exposure) and placebo (non-exposure) phases. in fact they are crossover of subjects between periods of exposure and non-exposure. this design ...
BACKGROUND Trials which test the effectiveness of interventions compared with the status quo frequently encounter challenges. The cohort multiple randomised controlled trial (cmRCT) design is an innovative approach to the design and conduct of pragmatic trials which seeks to address some of these challenges. MAIN TEXT In this article, we report our experiences with the first completed randomi...
BackgroundInguinal hernia belongs to the most common surgical pathology worldwide. Approximately, one third is asymptomatic. The value of watchful waiting (WW) in patients with asymptomatic or mildly symptomatic inguinal has been established a few randomised controlled trials (RCTs). aim this study was assess long-term outcomes RCT comparing WW and elective surgery.MethodsIn original study, men...
abstract background: menthol is the most important active material in mint and different mechanisms have been suggested for the way mint functions, most of which emphasize its analgesic effect owing to the presence of a group of temporary protein receptors. this study investigates the efficacy of peppermint capsule in the treatment of primary dysmenorrhea, in comparison with mefenamic acid and ...
BACKGROUND Clinical trials of therapies for spinal muscular atrophy (SMA) that are designed to increase the expression the SMN protein ideally include careful assessment of relevant SMN biomarkers. OBJECTIVE In the SMA VALIANT trial, a recent double-blind placebo-controlled crossover study of valproic acid (VPA) in ambulatory adult subjects with SMA, we investigated relevant pharmacodynamic b...
A double-blind crossover trial with 2-dimethylaminoethanol (Deanol), a possible precursor of brain acetylcholine, was carried out in nine patients with Huntington's chorea. It was found to be ineffective in inducing any alteration in hyperkinesia.
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