BACKGROUND The standard treatment for localised squamous cell carcinoma of the anal canal (SCCAC) is chemoradiotherapy (CRT) with infusional 5-fluorouracil (5-FU) and mitomycin. Because 5-FU and capecitabine have offered similar efficacy in many phase-III trials of solid tumours, studies have tested capecitabine in this setting of SCCAC. However, these studies are small and have reported variab...

A subset of people with diabetes fail to mount defensive counterregulatory responses (CRR) to hypoglycemia. Although the mechanisms by which this occurs remain unclear, recurrent exposure to hypoglycemia may be an important etiological factor. We hypothesized that loss of CRR to recurrent exposure to hypoglycemia represents a type of stress desensitization, in which limbic brain circuitry invol...

Electrocatalytic CO2 reduction reaction (CRR) is a promising way to convert carbon dioxide (CO2) into value-added hydrocarbons alleviate the ever-increasing environmental problem and accelerate realization of cycling. Cost-effective stable electrocatalytic materials with low overpotential, superior selectivity, excellent activity great stability are critically important achieve such target. Cu-...

OBJECTIVE The response of ventromedial hypothalamic (VMH) glucose-inhibited neurons to decreased glucose is impaired under conditions where the counterregulatory response (CRR) to hypoglycemia is impaired (e.g., recurrent hypoglycemia). This suggests a role for glucose-inhibited neurons in the CRR. We recently showed that decreased glucose increases nitric oxide (NO) production in cultured VMH ...

A major challenge for Streptococcus pyogenes vaccine development is the identification of epitopes that confer protection from infection by multiple S. pyogenes M-types. Here we have identified and characterised the distribution of common variant sequences from individual repeat units of the C-repeat region (CRR) of M-proteins representing 77 different M-types. Three polyvalent fusion vaccine c...

PURPOSE To describe the methodology and assess the reliability of novel computer-based semiautomated software that quantifies retinal arteriolar central light reflex (CR) from digital retinal photographs. METHODS A total of 150 optic disc-centered digital color retinal photographs were selected from a population-based cross-sectional study of persons aged 40 to 80 years (the Singapore Malay E...

We describe a method of model checking called Computing Range Reduction (CRR). The CRR method is based on derivation of clauses that reduce the set of traces of reachable states in such a way that at least one counterexample remains (if any). These clauses are derived by a technique called Partial Quantifier Elimination (PQE). Given a number n, the CRR method finds a counterexample of length le...

AIMS Hypoglycemia is a severe side effect of intensive insulin therapy. Recurrent hypoglycemia (RH) impairs the counter-regulatory response (CRR) which restores euglycemia. During hypoglycemia, ventromedial hypothalamus (VMH) production of nitric oxide (NO) and activation of its receptor soluble guanylyl cyclase (sGC) are critical for the CRR. Hypoglycemia also increases brain reactive oxygen s...

Preoperative 5-fluorouracil- (5-FU-) based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, the effect of 5-FU-based chemoradiotherapy on CRC is limited due to the development of chemoradiation resistance (CRR), and the molecular mechanisms underlying this resistance are yet to be investigated. Recently, circular RNAs (circRNAs), which can functio...