We investigate the cyclic behavior of laminate microstructures in finite-strain crystal plasticity and the resulting stress-strain response, based on a variational, incremental description of the microstructure evolution. The nonconvex free energy density in multiplicative singleand multi-slip plasticity gives rise to the formation of fine-scale deformation structures, experimentally observed a...

Cognitive and behavioral disorders are thought to be a result of neuronal dysfunction, but the underlying molecular defects remain largely unknown. An important signaling pathway involved in the regulation of neuronal function is the cyclic AMP/Protein kinase A pathway. We here show an essential role for coronin 1, which is encoded in a genomic region associated with neurobehavioral dysfunction...

The common approach to crystal-plasticity finite element modeling for load-bearing prediction of metallic structures involves the simulation simplified grain morphology and substructure detail. This paper details a methodology predicting structure–property effect as-manufactured microstructure, including true orientation, on cyclic plasticity, fatigue crack initiation in biomedical-grade CoCr a...