The results of liver perfusion experiments of Guggenheim and Loeffler (2) suggested that choline is oxidized to betainealdehyde (formylmethyltrimethyl ammonium ion). The products of reactions in vitro (3-6) exhibited the properties of betainealdehyde and betaine. It was shown that these products are formed by two enzymes of rat liver (7), choline oxidase of mitochondria (8, 9), and betainealdeh...

A new procedure for the synthesis of cyclohexanone-based inhibitors of serine proteases is reported. In this procedure the reactive ketone functionality is carried through the synthesis in masked form as a TBDMS-protected alcohol. Deprotection followed by oxidation of the alcohol generates the final form of the inhibitor. Two new inhibitors, which interact with the S1-S3 and S2' subsites of pla...

Cyclohexane oxidation is an important commercial reaction for the preparation of cyclohexanol and cyclohexanone, which are intermediates in the production of adipic acid and caprolactam respectively. These intermediates are important in the manufacture of nylon-6 and nylon-6,6 polymers (Yuan et al 2006 and Shylesh et al 2007). In addition, cyclohexanol and cyclohexanone are also used as solvent...

Absolute and relative rate techniques were used to study the reactivity of Cl atoms with cyclohexanone in 6 Torr of argon or 800–950 Torr of N2 at 295 ± 2 K. The absolute rate experiments gave k(Cl + cyclohexanone) = (1.88 ± 0.38) × 10−10, whereas the relative rate experiments gave k(Cl + cyclohexanone) = (1.66 ± 0.26) × 10−10 cm3 molecule−1 s−1. Cyclohexanone has a broad UV absorption band wit...

silica sulfuric acid is employed as solid acid catalyst for the clean and less hazardousprotection of carbonyl compounds as 2,4-dinitrophenylhydrazone under solvent-free conditions.

Silica sulfuric acid is employed as solid acid catalyst for the clean and less hazardousprotection of carbonyl compounds as 2,4-dinitrophenylhydrazone under solvent-free conditions.

Supercritical carbon dioxide and hydrogen peroxide was used in the oxidation for exploring a clean and efficient process to produce adipic acid. Supercritical carbon dioxide would be both a solvent and reactant in combination with aqueous hydrogen peroxide, which made the oxidation be possible through the formation of peroxycarbonic acid as the intermediate oxidizer. The effects of temperature ...

Enzyme stability is an important parameter in biocatalytic applications, and there is a strong need for efficient methods to generate robust enzymes. We investigated whether stabilizing disulfide bonds can be computationally designed based on a model structure. In our approach, unlike in previous disulfide engineering studies, short bonds spanning only a few residues were included. We used cycl...

Metal-free carbocatalysts enriched with specific oxygenated groups with different morphology and size were synthesized from glucose by hydrothermal carbonization, in which cheap and widely available biomass could be converted into functionalized carbon using an environmentally benign process. The hydroxy- and carbonyl-enriched hydrothermal carbon (HTC) could be used in nitrobenzene reduction, a...