introduction: cyclophosphamide (cp) is used for the treatment of various cancers. in spite of its therapeutic importance, a wide range of adverse effects such as reproductive toxicity has been observed following the administration of this drug in human and experimental animals. in the current study, we have investigated the adverse effects of cp on morphology and histology of testis rats. metho...

background: gonadotropin-releasing hormone (gnrh) is a reproductive key hormone. the gnrh analogues are widely used in in vitro fertilization and treatment of sex hormone-depended cancers induced by the materials used in chemotherapeutic agents. objective: the aim of this study is to evaluate the effects of cyclophosphamide and decapeptyl (analogues of gnrh) on histomorphometry and stereology o...

introduction and objective: liver is an important body organ without which life is impossible. cyclophosphamide is an alkylating agent widely used as an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. the present study aimed to find a suitable antioxidant and examine the effect of vitamin e and selenium on reducing the side effects of cyclophosphamide on liver as a vital organ....

Cyclophosphamide is one of the chemotherapeutics for cancer, however this drug has severe side effects in multiple organs and a well-known mutagenic agent. In work protective activity antioxidant-rich Carob (Ceratonia siliqua L.) pods leaves extracts against cyclophosphamide induced genotoxicity was studied. Safety these evaluated acute subacute toxicity tests at dose 1500 mg/kg/day albino rats...

Introduction and Objective: liver is an important body organ without which life is impossible. Cyclophosphamide is an alkylating agent widely used as an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. The present study aimed to find a suitable antioxidant and examine the effect of vitamin E and selenium on reducing the side effects of cyclophosphamide on liver as a vit...

Introduction and Objective: liver is an important body organ without which life is impossible. Cyclophosphamide is an alkylating agent widely used as an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. The present study aimed to find a suitable antioxidant and examine the effect of vitamin E and selenium on reducing the side effects of cyclophosphamide on liver as a vit...

Cyclophosphamide, a chemotherapeutic and immunosuppressive drug, has been linked to problems after bone marrow transplantation in the past. More recently, it demonstrated that cardiotoxicity limits dose of cyclophosphamide, cardiology is receiving more attention. Though exact mechanism cyclophosphamide-induced unknown, oxidative nitrative stress are suspected play role. As result, focus this re...

Cyclophosphamide (CP) is a cytotoxic alkylating agent it's used associated with different side effects including lung toxicity. Vitamin B2 and vitamin B12 have lung-protective effects. This study was designed to evaluate of both vitamins against toxicity induced by cyclophosphamide. seventy healthy adult albino male female rats divided into seven groups each group containing ten were in the pre...