BACKGROUND Chlorpyrifos is one of the most widely used organophosphate insecticides in the United States. Although the toxicity of chlorpyrifos has been extensively studied in animals, the epidemiologic data are limited. OBJECTIVE To evaluate whether agricultural chlorpyrifos exposure was associated with mortality, we examined deaths among pesticide applicators in the Agricultural Health Stud...

A growing body of scientific evidence suggests there may be an association between parents' exposure to pesticides and cancer in their children. In this issue, Kori Flower of the University of North Carolina–Chapel Hill School of Public Health and colleagues report the results of their recent study investigating the possibility of increased cancer risk among the children of pesticide applicator...

BACKGROUND AND PURPOSE To elaborate a method for applicator reconstruction for MRI-based brachytherapy for cervical cancer. MATERIALS AND METHODS Custom-made plastic catheters with a copper sulphate solution were made for insertion in the source channels of MR-CT compatible applicators: plastic and titanium tandem ring applicators, and titanium needles. The applicators were CT and MR scanned ...

BACKGROUND Chlorpyrifos is one of the most widely used insecticides in the United States. We evaluated the incidence of cancer among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina. METHODS A total of 54,383 pesticide applicators were included in this analysis. Detailed info...

Averaged across crop, year and season , residue cover reduction was significantly less for coulter-type applicators than for disk-type applica-tors (P<0.001), disk-type applicators reduced residue cover significantly less than chisel and sweep injectors (P<0.001), and chisel and sweep injec-tors reduced residue cover similar to a tandem disk (P=0.398). Ranges of values to estimate the percentag...

Interstitial ultrasound applicators have been proposed for treating deep-seated tumours that cannot be reached with extra-corporeal high-intensity focused ultrasound. In addition, interstitial ultrasound offers several advantages compared with conventional ablation technology (radiofrequency, microwaves, cryotherapy) in terms of penetration, speed of coagulation, ability to direct and control t...

OBJECTIVES An epidemiological study of 90 male pesticide applicators licensed in New York was conducted to investigate the effect of exposure to organophosphate pesticides on the peripheral nervous system. METHODS A cohort of farmers and pesticide applicators from New York State were questioned off season (November 1988-February 1989) and again during the spraying season (April 1989-August 19...

OBJECTIVES Although the primary hazard to humans associated with pesticide exposure is acute poisoning, there has been considerable concern surrounding the possibility of cancer and other chronic health effects in humans. Given the huge volume of pesticides now used throughout the world, as well as environmental and food residue contamination leading to chronic low level exposure, the study of ...

Pesticide exposure has been associated with acute and chronic adverse health effects. DNA methylation (DNAm) may mediate these effects. We evaluated the association between experiencing unusually high pesticide exposure events (HPEEs) and DNAm among pesticide applicators in the Agricultural Health Study (AHS), a prospective study of applicators from Iowa and North Carolina. DNA was extracted fr...