نتایج جستجو برای: cyp2c19 polymorphisms

تعداد نتایج: 68456  

2013
Payman Shahabi Gérard Siest Bernard Herbeth Daniel Lambert Christine Masson Jean-Sébastien Hulot Sébastien Bertil Pascale Gaussem Sophie Visvikis-Siest

We aimed to assess the association between the most common polymorphisms of cytochrome P450 (CYP) epoxygenases on the plasma levels of inflammatory markers in a population of healthy subjects. We also sought to determine whether CYP2C19 2 polymorphism is associated with the anti-inflammatory response to clopidogrel. In a population of 49 healthy young males, the baseline plasma levels of inflam...

Journal: :Clinical pharmacology and therapeutics 2013
J K Hicks J J Swen C F Thorn K Sangkuhl E D Kharasch V L Ellingrod T C Skaar D J Müller A Gaedigk J C Stingl

Polymorphisms in CYP2D6 and CYP2C19 affect the efficacy and safety of tricyclics, with some drugs being affected by CYP2D6 only, and others by both polymorphic enzymes. Amitriptyline, clomipramine, doxepin, imipramine, and trimipramine are demethylated by CYP2C19 to pharmacologically active metabolites. These drugs and their metabolites, along with desipramine and nortriptyline, undergo hydroxy...

2006
NEGIN ZAND NADER TAJIK MAHMOOD HOORMAND ALIREZA SALEK MOGHADDAM

Cytochrome P450 2C19 (CYP2C19) plays an important role in the metabolism and elimination of a wide range of medications. The polymorphisms of this enzyme give rise to substantial inter-individual and interethnic variability in drug excretion rates and final serum concentrations. For this reason, therapeutic responses and adverse drug reactions may vary from one person to another. In this study ...

Background: Clopidogrel is a standout amongst the most ordinarily recommended medications to avoid ischemic occasions taking after coronary disorder or stant position. However, impaired responses the therapy as well as resistance to the therapy have also been reported. Genetic variants play an important role in clopidogrel biotransformation of its active metabolite that may subsequently influen...

Journal: :Biological & pharmaceutical bulletin 2012
Naoki Matsuzawa Katsunori Nakamura Masayuki Matsuda Fumihiro Ishida Shigeru Ohmori

PURPOSE Cytochrome P450 (CYP)2C19 polymorphisms may partly explain the variability of thalidomide concentration and adverse drug effects by altering its metabolism. To compare the genetic and clinical factors responsible for the adverse effects and efficacy of thalidomide treatment, we investigated CYP2C19 genetic polymorphisms in Japanese subjects. MATERIALS AND METHODS Variations in the CYP...

2014
Damrus Tresukosol Bhoom Suktitipat Saowalak Hunnangkul Ruttakarn Kamkaew Saiphon Poldee Boonrat Tassaneetrithep Atip Likidlilid Carmine Pizzi

Clopidogrel is an antiplatelet prodrug that is recommended to reduce the risk of recurrent thrombosis in coronary artery disease (CAD) patients. Paraoxonase 1 (PON1) is suggested to be a rate-limiting enzyme in the conversion of 2-oxo-clopidogrel to active thiol metabolite with inconsistent results. Here, we sought to determine the associations of CYP2C19 and PON1 gene polymorphisms with clopid...

Journal: :Toxicology Letters 2021

Quantifying variability in pharmacokinetics (PK) and toxicokinetics (TK) provides a science-based approach to refine uncertainty factors (UFs) for chemical risk assessment. In this context, genetic polymorphisms cytochromes P450 (CYPs) drive inter-phenotypic differences may result reduction or increase metabolism of drugs other xenobiotics. Here, an extensive literature search was performed ide...

2013
Xiang Xie Yi-Tong Ma Yi-Ning Yang Xiao-Mei Li Xiang Ma Zhen-Yan Fu Ying-Ying Zheng Bang-Dang Chen Fen Liu

BACKGROUND Several studies have indicated that CYP2C19 loss-of-function polymorphisms have a higher risk of stent thrombosis (ST) after percutaneous coronary interventions (PCIs). However, this association has not been investigated thoroughly in a Chinese population. In this study, we aimed to determine the effect of CYP2C19*2 and CYP2C19*3 loss-of-function polymorphisms on the occurrence of ST...

2007
Yuichi SAKURAI Masashi HIRAYAMA Muneaki HASHIMOTO Takanori TANAKA Setsuo HASEGAWA Shin IRIE Kiyoshi ASHIDA Yuichiro KAYANO Masato TAGUCHI Yukiya HASHIMOTO

causes of emergency hospital admission in Japan, and it possibly results in life-threatening massive hemorrhage. Endoscopic clipping of the bleeding vessel is usually effective for treating gastrointestinal hemorrhage, but rebleeding occurs in 15 to 20% of patients. Higher intragastric pH promotes platelet aggregation, and the inhibition of gastric acid secretion to maintain neutral pH may stab...

2017
Yun-An Lin Hong Wang Zhu-Jun Gu Wen-Jia Wang Xiao-Yan Zeng Yan-Lei Du Song-Song Ying Bo-Hua Zhang

BACKGROUND The effects of PPI are variable owing to the CYP2C19 polymorphisms. However, whether the polymorphisms could affect the Hp eradication efficacy of triple therapy is still not clear. The present study aimed to assess the effects of CYP2C19 gene polymorphisms on proton pump inhibitor (PPI), amoxicillin, and levofloxacin triple therapy for Helicobacter pylori (Hp) eradication. MATERIAL ...

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