conventional cytogenetic is the standard technique for detection of philadelphia (ph) chromosome in chronic myeloid leukemia (cml). evaluation of abelson murine leukemia/breakpoint cluster region (abl/bcr) fusion using dual-colour fluorescence in situ hybridization (d-fish) is an alternative approach allowing rapid and reliable detection of the disease. we employed the technique of interphase d...

BACKGROUND The prognostic value of cytogenetic findings in chronic myelomonocytic leukemia is unclear. Our purpose was to evaluate the independent prognostic impact of cytogenetic abnormalities in a large series of patients with chronic myelomonocytic leukemia included in the database of the Spanish Registry of Myelodysplastic Syndromes. DESIGN AND METHODS We studied 414 patients with chronic...

Background: Pancytopenia is a manifestation of a wide range of disorders. The main prognostic factor for predicting outcome and response to treatment is based on the underlying cause. To detect the root cause of this problem, depending on other accompanied signs or symptoms, the need for bone marrow examination and other advanced work ups is different at least at the practical level. This study...

PURPOSE To propose an alternative hypothesis for the observed differential survival of patients with small, medium, and large choroidal melanomas based on recently uncovered cytogenetic evidence about melanocytic choroidal tumors. METHODS Review and analysis of published data. RESULTS Recent evidence has shown that recurring nonrandom cytogenetic abnormalities are present within virtually a...

Background: Diagnostic karyotyping analysis is routinely used in acute myeloid leukemia (AML) clinics. Categorization of patients into risk stratified groups (favorable, intermediate and adverse) according to cytogenetic findings can serve as a valuable independent prognostic factor. Method and Material: A retrospective descriptive study was conducted based on the patient records of newly diagn...

Cytogenetic clonal evolution (CE) is a known poor prognostic factor in Philadelphia chromosome-positive chronic myelogenous leukemia (Ph-positive CML). However, its prognostic relevance in the era of imatinib therapy is unknown. We investigated the independent prognostic relevance of CE in 498 patients with Ph-positive CML treated with imatinib for chronic or accelerated phases. One hundred twe...

in the present paper, the cytogenetic study including meiotic chromosome number and behavior along with pollen viability were performed in 4 populations of trigonella spruneriana boiss. this is the first cytogenetic report of the taxon. all populations are diploid and possess 2n = 2x = 16 chromosome number, which is consistent with the proposed basic number of x = 8. in addition, some meiotic i...

A new zero–inflated Poisson model is introduced for cytogenetic estimation of partial body radiation dose and fraction of the body irradiated. Bayes factors are also presented to detect if a sample of chromosomal aberrations in blood cells results from partial or whole body irradiation. One example of simulated cytogenetic exposure is shown to demonstrate the usefulness of this methodology in c...

Cytogenetic analysis has not only provided important information on the pathogenesis of soft tissue tumors but, by disclosing distinct chromosomal rearrangements in different histopathological entities, has also come to serve as a valuable diagnostic tool. Little is known as yet about the potential prognostic impact of cytogenetic features detected in these tumors. A total of 239 benign and 221...