The study of chromosomal aberrations has facilitated the understanding of tumorigenesis. By applying molecular genetic techniques to regions highlighted by cytogenetic study, many genes important in tumorigenesis have been identified. This review will describe the cytogenetic and molecular cytogenetic techniques used to identify these changes. The clinical information that they can provide, inc...

Background & Aims: Induced pluripotent stem cells (iPSCs) have the capability to undergo unlimited selfrenewal and differentiation into all cell types in the body. These cells are artificially derived from a nonpluripotent cell, typically human dermal fibroblasts (HDFs). The study of cytogenetic stability of these cells, in order to use iPS cells and apply studies in therapeutic applications, i...

a cytogenetic study was performed on 11 tetraploid cotton cultivars (gossypium hirsutum l.)including the oltan cultivar and its crossing progenies. the chromosome pairing and chiasma frequency, aswell as meiotic abnormalities were compared among the genotypes studied. heterozygote translocations withalternate orientation were observed between some of the chromosomes of the a genome and those of...

INTRODUCTION Imatinib mesylate, a selective Bcr-Abl tyrosine kinase inhibitor, has proved to be most effective therapy of Philadelphia chromosome-positive chronic myelogenous leukemia. Imatinib induces complete haematological and cytogenetic response in high percentage of patients. OBJECTIVE The aim of this study was to identify potential prognostic factors before beginning treatment with ima...

background & aim: alhagi genus has two important  medicinal plant species in iran, including alhagi pseudoalhagi, and a. graecorum (known “kharshotor” in persian). these plants are distributed in iran like weeds. generally, alhagi is used as an anti-hemorrhoid, laxative and diuretic. manna in both species produced by activity of a kind of insect on alhagi branches which has medicinal proper...

in the present paper, the cytogenetic study including meiotic chromosome number and behavior along with pollen viability were performed in 4 populations of trigonella spruneriana boiss. this is the first cytogenetic report of the taxon. all populations are diploid and possess 2n = 2x = 16 chromosome number, which is consistent with the proposed basic number of x = 8. in addition, some meiotic i...