نتایج جستجو برای: d1b and pinb
تعداد نتایج: 16827190 فیلتر نتایج به سال:
A unique class of β-boron-functionalized non-steroidal anti-inflammatory compound (pinB-NSAID) was previously synthesized via copper-catalyzed 1,2-difunctionalization the respective vinyl arene with CO2 and B2pin2 reagents. Here, pinacolylboron-functionalized ibuprofen (pinB-ibuprofen) used as a model substrate to develop conditions for pinacol deprotection subsequent boron functionalization. I...
The well-defined copper(I) boryl complex [(IPr)Cu(Bpin)] [where IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene, and pin = pinacolate: 2,3-dimethyl-2,3-butanediolate] deoxygenates CO2 rapidly and quantitatively, affording CO and the borate complex [(IPr)Cu(OBpin)]. The boryl may be regenerated by treatment with the diboron compound pinB-Bpin, giving the stable byproduct pinB-O-Bpin. The ...
These notes about the activities of the two Spanish Collaborating Research Groups (CRG) at the Institut Laue Langevin (ILL) are written to give a historical view of the group and to present the two new instrumental projects currently in development. After a brief description of the instruments with current Spanish participation (D1B and D15), it will be presented the project of construction of ...
Glycogen synthase kinase-3beta-dependent phosphorylation of cyclin D1 at a conserved COOH-terminal residue, Thr-286, promotes CRM1-dependent cyclin D1 nuclear export at the G(1)-S boundary. Mutations that perturb the phosphorylation of cyclin D1 at Thr-286 contribute to cell transformation, although to date, no such mutations have been found in human cancers. Cyclin D1 (CCND1) undergoes alterna...
PURPOSE Alternative CCND1 splicing results in cyclin D1b, which has specialized, protumorigenic functions in prostate not shared by the cyclin D1a (full length) isoform. Here, the frequency, tumor relevance, and mechanisms controlling cyclin D1b were challenged. EXPERIMENTAL DESIGN First, relative expression of both cyclin D1 isoforms was determined in prostate adenocarcinomas. Second, releva...
Dopamine D1-like receptors consist of D1 (D1A) and D5 (D1B) receptors and play a key role in working memory. However, their possibly differential contribution to working memory is unclear. We combined a working memory training protocol with a stepwise increase of cognitive subcomponents and real-time RT-PCR analysis of dopamine receptor expression in pigeons to identify molecular changes that a...
Cyclin D1 is an important cell cycle regulator but in cancer its overexpression also increases cellular migration mediated by p27 stabilization and RhoA inhibition. Recently, a common polymorphism at the exon 4-intron 4 boundary of the human cyclin D1 gene within a splice donor region was associated with an altered risk of developing cancer. Altered RNA splicing caused by this polymorphism give...
The receptors of the dopamine neurotransmitter belong to two unrelated classes named D1 and D2. For the D1 receptor class, only two subtypes are found in mammals, the D1A and D1B, receptors, whereas additional subtypes, named D1C, D1D, and D1X, have been found in other vertebrate species. Here, we analyzed molecular phylogeny, gene synteny, and gene expression pattern of the D1 receptor subtype...
Abstract Molecular β‐diketiminato (BDI) calcium hydride and n ‐hexyl derivatives are shown to display contrasting reactivities toward bis(pinacolato)diboron (B 2 pin ). Whereas the dimeric constitution of is retained during formation an unusual diborane(6) dianion, initially organocalcium reagent converted a diboranate monomer, [(BDI)Ca{pinB‐Bpin( ‐hex)}]. Attempts effect heterolysis B−B bond t...
It has been well documented that dwarfing genes Rht-B1b and Rht-D1b are associated with Type I susceptibility to Fusarium head blight (FHB) in wheat; but the underlying mechanism has not been well delineated. Anther extrusion (AE) has also been related to Type I resistance for initial FHB infection, where high AE renders FHB resistance. In this study, two doubled haploid populations were used t...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید