The microbial community in the human colon contains bacteria that reduce cholesterol to coprostanol, but the species responsible for this conversion are still unknown. We describe here the first isolation and characterization of a cholesterol-reducing bacterium of human intestinal origin. Strain D8 was isolated from a 10(-8) dilution of a fresh stool sample provided by a senior male volunteer w...

D8 and Mpl1 are two dominant dwarfing mutations of maize. Although they differ in severity of dwarfism, both D8 and Mpl1 mutants are unresponsive to gibberellin (GA). Because of their close phenotypic resemblance to the recessive GA-sensitive dwarf mutants these dominant mutations may identify a gene whose product is involved in the reception of GA. With this possibility in mind we have studied...

Cucumber is an economically important vegetable crop worldwide. Powdery mildew (PM) is one of the most severe diseases that can affect cucumber crops. There have been several research efforts to isolate PM resistance genes for breeding PM-resistant cucumber. In the present study, we used a chromosome segment substitution line, SSL508-28, which carried PM resistance genes from the donor parent, ...

We show that N = 2 supersymmetric Maxwell-Chern-SimonsHiggs systems in three dimension can be realized as gauge theories on a D2-brane in D8-branes background with a non-zero B-field. We reproduce a potential of Coulomb branch of the Chern-Simons theory as a potential of a D2-brane in a classical D8-brane solution and show that each Coulomb vacuum is realized by a D2-brane stabilized in the bul...

BACKGROUND Radiation therapy is a well-recognized, effective modality used for palliative care. Most studies completed to date have endpoints of one month or greater after treatment completion. This study analyzed the response rates at different time points during the first month after treatment. METHODS From May 2010 to November 2011, 61 patients treated for 74 metastases were included in th...

We consider non-BPS D8 (and D7) branes in type 0 open string theory and describe under which circumstances these branes are stable. We find stable non-BPS D7 and D8 in type 0 with and without D9-branes in the background. By extending the descent relations between D-branes to type 0 theories, the non-BPS D8-brane is considered as the result of a tachyon condensation of a D9 anti-D9 pair in type ...

The H-2Dd transgenic strain D8 on C57BL background was more resistant to subcutaneous challenge of RBL-5 lymphoma cells than B6 controls. The direct role of the H-2Dd antigen was investigated by the use of (D8 x B6)F1 crosses and (D8 B6) x B6 backcrosses. The latter showed cosegregation with regard to Dd antigen expression and lymphoma resistance, both of which were inherited in a pattern consi...

Tirbanibulin 1% ointment was approved for actinic keratosis (AK) of face or scalp based on two Phase 3 trials. Pooled rates complete (100%) clearance (CC) and partial (≥75%) (PC) in these trials were reported Day (D) 57 treatment, being 49% 72% respectively. We present post-hoc efficacy safety analyses evaluating earlier time points. Participants (N=702) the had 4-8 clinically visible AK lesion...

Techniques for detecting and quantifying anaerobic transformations of benzene, toluene, ethylbenzene, and xylene (BTEX) are needed to assess the feasibility of using in situ bioremediation to treat BTEX-contaminated groundwater aquifers. Deuterated surrogates of toluene (toluene-d8) and xylene (o-xylene-d10) were injected into BTEX-contaminated aquifers during single-well push-pull tests to mon...