The DNA of all cells is continually under assault from a wide range of DNA-damaging agents. To counter this threat to their genetic integrity, cells possess systems, collectively known as the DDR (DNA-damage response), to detect DNA damage, signal its presence and mediate its repair. In the present article, I provide an overview of the DDR and then describe how work in my laboratory and elsewhe...

normal skin is composed of epidermis and dermis. skin is susceptible to radiation damage because it is a continuously renewing organ containing rapidly proliferating mature cells. radiation burn is a damage to the skin or other biological tissues caused by exposure to radiofrequency energy or ionizing radiation. acute skin reaction is the most frequently occurring side effect of radiation thera...

this paper presents an experimental study the influence of wave parameter on the damage of reshaping seawall, model tests have been performed in several water level conditions. the experiments of physical modeling of this research have been done in the flume of the soil conservation and watershed management research institute (scwmri). the waves applied to the structure model are irregular and ...

kermanshah province is the main producer of various chickpea cultivars in iran. in this study a laboratory peg-tooth thresher was employed for chickpea threshing. the effect of cylinder speed (9, 12, 15 m/s), concave clearance (12, 14, 16 mm), feed rate (80, 160, 240 kg/h) and material moisture content (5, 10, 15% w.b.) was studied on percentage of grain damage, threshing efficiency and percent...

dust storms are catastrophic natural disasters that beside other disasters frequency occur in the arid and semiaridregions worldwide. drought occurrence, climate aridity, dryness of the hamoun lake cause strong winds to below.these conditions have been prepared for dust storms in sistan region. the damages to sistan society have beenmeasured using different criteria. the result shows that, peak...

dust storms are catastrophic natural disasters that beside other disasters frequency occur in the arid and semiaridregions worldwide. drought occurrence, climate aridity, dryness of the hamoun lake cause strong winds to below.these conditions have been prepared for dust storms in sistan region. the damages to sistan society have beenmeasured using different criteria. the result shows that, peak...

prolonged local consumption of anethum graveolens leaves, as an antihyperlipimic and antihypercholesterolemic agent, has been associated in some patients with skin disorders such as darkening and pigmentation mainly in the exposed areas such as face and hands.anethum graveolens belongs to the umbelliferae family which is belived to be rich in photoactive furocoumarins. an oraganic extract of th...

objective:coriandrum sativum (c. sativum) as a medicinal plant has been pointed to have analgesic, hypnotic and anti-oxidant effects. in the current study, a possible preventive effect of the hydro-alcoholic extract of the plant on neuronal damages was examined in pentylenetetrazole (ptz) rat model of seizure.materials and methods: forty male rats were divided into five main groups and treated ...

objective(s): gentamicin is used for the treatment of gram-negative bacterial infections. however, gentamicin administration is limited because of nephrotoxicity. the aim of the present study was to evaluate the protective effect of crocin against gentamicin-induced nephrotoxicity in rats. materials and methods: thirty two male wistar rats received gentamicin (100 mg/kg, ip), with or without cr...

objective: this study aimed to assess the value of chlamydia trachomatis (c.trachomatis) antibodytiter test in prediction of  tubal damage. materials and methods : in this case-control study we enrolled50 women with tubal factor infertility (proven by laparoscopy after hysterosalpingography) and 110 women without infertility history. elisa was performed for all participants, seeking c.trachomat...