Dibenzo[def,p]chrysene (DBC) is the most carcinogenic polycyclic aromatic hydrocarbon (PAH) examined to date. We investigated the immunotoxicity of DBC, manifested as spleen atrophy, following acute exposure of adult MutaMouse males by oral gavage. Mice were exposed to 0, 2.0, 6.2, or 20.0 mg DBC /kg-bw per day, for 3 days. Genotoxic endpoints (DBC-DNA adducts and lacZ mutant frequency in splee...

Black carbon (BC) is a byproduct of combustion from wildfires and fossil fuels and is a slowcycling component of the carbon cycle. Whether BC accumulates and ages on millennial timescales in the world oceans has remained unknown. Here, we quantified dissolved BC (DBC) in marine dissolved organic carbon (DOC) isolated by solid phase extraction (SPE) at several sites in the world ocean. We find t...

We present the Distributed Batch Controller (DBC}, a system built to support batch processing of large scienti$c datasets. The DBC implements a federation of autonomous workstation pools, which may be widely distributed. Individual batch ,jobs are executed using idle workstations in these pools. Input data are staged to the pool before processing begins. We describe the architecture and impleme...

Bad smells are usually related to program source code, arising from bad design and programming practices. Refactoring activities are often motivated by the detection of bad smells. With the increasing adoption of Design-by-Contract (DBC) methodologies in formal software development, evidence of bad design practices can similarly be found in programs that combine actual production code with inte...

The photochemistry of 5-diazo-10,11-dihydrodibenzo[a,d]diazocycloheptene (DDBC) and 9-diazoanthrone (DAN) were studied by ultrafast time resolved techniques. The excited states of these diazo compounds were observed by UV-Vis spectroscopy and were found to decay in 300 fs. The diazo excited state decays led to the appearance and first direct observation of singlet 5-diazo-10,11-dihydrodibenzo[a...

The protein expression of the growth suppressive p53 transcription factor and its inhibitor human double minute 2 (Hdm2) is altered in ductal breast carcinomas (DBC). However, the assessment of p53 and/or Hdm2 protein levels in DBC tissues was found to have a questionable prognostic significance. We evaluated the RNA expression of p53, hdm2, and the p53-targeted p21waf-1 and thrombospondin (tsp...

Design by Contract (DbC) is a software development methodology that focuses on clearly defining the interfaces between components to produce better quality object-oriented software. The idea behind DbC is that a method defines a contract stating the requirements a client needs to fulfill to use it, the precondition, and the properties it ensures after its execution, the postcondition. Though th...

For decades now, modular design methodologies have helped software engineers cope with the size and complexity of modern-day industrial applications. To be truly effective though, it is essential that module interfaces be rigorously specified. Design by Contract (DBC) is an increasingly popular method of interface specification for object-oriented systems. Many researchers are actively adding s...

In this paper, a new image indexing and retrieval algorithm using multiresolution directional binary code (DBC) co-occurrence matrix is proposed. DBC histogram captures only the patterns distribution in a texture while the spatial correlation between the pair of patterns is gathered by DBC Co-occurrence. Multi-resolution texture decomposition and co-occurrence calculation has been efficiently u...

Changes in soft-bottom macrobenthic communities and the effects of anthropogenic disturbances were studied. We compared biological and environmental samples during and after bridge construction (DBC and ABC). Significant differences were detected in sediment composition at three stations, although hydrographic conditions were similar for DBC and ABC samples. From DBC to ABC, the number of speci...