A 2-GHz direct digital frequency synthesizer (DDFS) chip-set is presented which operates at a very low supply voltage of 2 V. The chip-set consists of a CMOS DDFS-large scale integrator (LSI) which synthesizes a sine wave at 55 Msps with an internal 10-b digital-to-analog converter (DAC) and Si-bipolar image-reject up-converters. To achieve both high purity and low power dissipation, we develop...

this paper presents a modified 32-bit rom-based direct digital frequency synthesizer (ddfs). maximum output frequency of the ddfs is limited by the structure of the accumulator used in the ddfs architecture. the hierarchical pipeline accumulator (hpa) presented in this paper has less propagation delay time rather than the conventional structures. therefore, it results in both higher maximum ope...

CORDIC algorithms have long been used in digital signal processing for calculating trigonometric, hyperbolic, logarithmic and other transcendental functions. The algorithm requires only shift and add operations and this simplicity encourages its implementation in hardware. Traditional CORDIC architectures have focused on radix-2 implementations because of their higher accuracy. However these ar...

BACKGROUND The authors evaluated the two indicators of metastatic proclivity (namely, virulence [V; the rate of appearance of distant metastases] and metastagenicity [M; the ultimate likelihood of developing distant metastases]) of breast carcinoma in elderly women. The authors then compared these characteristics with the corresponding characteristics in a cohort of younger women to determine w...

BACKGROUND Overexpression of the erbB-2 protein by breast cancer cells has been suggested to be a predictor of response to doxorubicin. A retrospective study was designed to test this hypothesis. METHODS In National Surgical Adjuvant Breast and Bowel Project protocol B-11, patients with axillary lymph node-positive, hormone receptor-negative breast cancer were randomly assigned to receive eit...

Given the critical role of CYP19 in estrogen synthesis, we investigated the influence of CYP19 gene polymorphisms on the clinical outcome of lymph node- (LN-) negative, hormone receptor- (HR-) positive early breast cancers. Genotyping for the CYP19 polymorphisms rs4646 (A/C), rs1065779 (A/C), CYP19 (TTTA)n (short allele/long (S/L) allele using the 7 TTTA repeat polymorphism as the cut-off), and...

BACKGROUND We have previously shown the prognostic importance of tumor-infiltrating lymphocytes (TILs) in newly diagnosed triple-negative breast cancer (TNBC) using tumor samples from a large clinical trial cohort. In this study, we aimed to validate these findings and also investigate associations with trastuzumab benefit in HER2-overexpressing disease (HER2+). PATIENTS AND METHODS A prospec...

Because of their ability to induce local immunosuppression and to confer cancer cells with resistance to apoptosis, members of the galectin family are emerging as a new class of actionable targets in cancer. Unfortunately, we have yet to obtain a clear picture of the galectin signatures in cancer cells and the surrounding tumor microenvironment. The aim of this study was to provide the first de...

PURPOSE Controversy exists regarding estrogen (ER) and progesterone (PgR) receptor expression on efficacy of adjuvant endocrine therapy. In the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial, the benefit of anastrozole over tamoxifen was substantially greater in ER+/PgR-than ER+/PgR+ tumors. In BIG 1-98 (Breast International Group), the benefits of letrozole over tamoxifen were the s...

PURPOSE Breast cancers in carriers of inactivating mutations of the BRCA1 gene carry a specific DNA copy-number signature ("BRCA1-like"). This signature is shared with cancers that inactivate BRCA1 through other mechanisms. Because BRCA1 is important in repair of DNA double-strand breaks through error-free homologous recombination, patients with a BRCA1-like tumor may benefit from high-dose alk...