نتایج جستجو برای: decalin

تعداد نتایج: 200  

2011
Da Xu Michael A Drahl Lawrence J Williams

The synthesis of a model endocyclic allene related to the vernonia allenes is described. Fragmentation of a suitable decalin derivative gave the simplified germacrane scaffold. Computational analysis of this and related substrates provides insight into the stereoelectronic requirements of C-C fragmentation. The overall strategy to access these and other sesquiterpenes and the key steps in the p...

2016
W. Poon J. Selfe M. Robertson S. Ilett A. Pirie P. Pusey

We report an experimental study of the phase bebaviour of a model hard sphere colloid + non-adsorbing polymer mixture sterically stabilised PMMA (radius = 217 nm) and polystyrene (r~ = 12.8 nm ) in cis-decalin. It was found'that the main effect of adding polymer was to expand the fluid-crystal coexistence region of the colloidal suspension, which

Journal: :The Journal of antibiotics 2004
Tetsuya Someno Hiroyuki Kumagai Shun-ichi Ohba Masahide Amemiya Hiroshi Naganawa Masaaki Ishizuka Daishiro Ikeda

ICM0301A (1), B (2) and their congeners (3 approximately 8) were isolated from a culture broth of Aspergillus sp. F-1491 as new angiogenesis inhibitors. Their structures were elucidated by spectroscopic analyses. ICM0301A and B have a substituted decalin skeleton containing two oxirane rings.

Journal: :Angewandte Chemie 2015
K C Nicolaou Akshay A Shah Henry Korman Tabrez Khan Lei Shi Wisuttaya Worawalai Emmanuel A Theodorakis

The total synthesis and structural revision of antibiotic CJ-16,264 is described. Starting with citronellal, the quest for the target molecule featured a novel bis-transannular Diels-Alder reaction that casted stereoselectively the decalin system and included the synthesis of six isomers before demystification of its true structure.

2014
James Whitt Suzanne M. Shipley David J. Newman Karina M. Zuck

Coculture of the fungus Fusarium pallidoroseum with the bacterium Saccharopolyspora erythraea was found to produce three new decalin-type tetramic acid analogues related to equisetin. The structures were determined by spectroscopic methods. The absolute configurations were established by circular dichroism spectroscopy and comparing the data with those of equisetin.

Journal: :Organic & biomolecular chemistry 2005
Alan C Spivey Jacqueline Colley Lindsey Sprigens Susan M Hancock D Stuart Cameron Kordi I Chigboh Gemma Veitch Christopher S Frampton Harry Adams

The syntheses of three decalin-based tert-thiols displaying varying degrees of solubility in aqueous milieu are described. The S-nitroso derivatives of these compounds have also been prepared and the structures of two of these determined by single crystal X-ray diffraction. These compounds have been designed for studying the interaction of nitric oxide (NO) with thiols under physiological condi...

Journal: :The Journal of biological chemistry 2003
Lieve Verlinden Annemieke Verstuyf Christel Verboven Guy Eelen Camiel De Ranter Ling-Jie Gao Yong-Jun Chen Ibrahim Murad Mihwa Choi Keiko Yamamoto Sachiko Yamada Dirk Van Haver Maurits Vandewalle Pierre J De Clercq Roger Bouillon

Deletion of C19 in the structure of 1 alpha,25-dihydroxyvitamin D3 [1,25(OH)2D3] does not substantially alter the biological potency but prevents the conversion between the vitamin and the previtamin form. Hence, this modification allows the study of locked previtamin and vitamin forms. The locked 19-nor-1,25(OH)2-previtamin D3 analog (19-nor-previtamin D) had a low biological activity and was ...

Journal: :Organic & biomolecular chemistry 2005
Guanglin Bao Liang Zhao D Jean Burnell

A synthetic sequence is described for construction of the tricyclic portion (35) of kempane diterpenes. The central stereochemistry was established by a Diels-Alder addition of 2,6-dimethyl-para-benzoquinone to a 5-membered, dithiane-protected diene, and the addition of acetylide, with very high chemoselectivity, provided a suitably functionalized handle that will be incorporated into the final...

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