In this work we follow the polyethylcyanoacrylate nanoparticles through human skin. Photoluminescence (PL) is used to quantify the amount of these nanocarriers into the layers of the skin stratum corneum (SC). To obtain samples of each layer of SC, tape stripping technique was conducted. Reproducible data were obtained, and the nanoparticles’ distribution in each layer of the SC is presented. P...

This study used structural equation modeling to examine the effect of Stratum III (i.e., general intelligence) and Stratum II (i.e., Comprehension-Knowledge, Fluid Reasoning, Short-Term Memory, Processing Speed, and Visual Processing) factors of the Cattell-Horn-Carroll (CHC) cognitive abilities, as operationalized by the Wechsler Intelligence Scale for Children, Fourth Edition (WISC-IV; Wechsl...

Monocarboxylate-H+ cotransporters, such as monocarboxylate transporter (MCT) SLC16A, have been suggested to mediate transruminal fluxes of short-chain fatty acids, ketone bodies, and lactate. Using an RT-PCR approach, we demonstrate expression of MCT1 (SLC16A1) and MCT2 (SLC16A7) mRNA in isolated bovine rumen epithelium. cDNA sequence from these PCR products combined with overlapping expressed ...

Abstract River deltas, where ocean tides can often freely propagate into the river, are focal points of human settlement. Beneath delta surface, groundwater stored in soil strata fluctuates with river tides, resulting pressure variations within strata. Here, we introduce a novel ultra‐weak fiber‐optic instrument to test hypothesis that tide‐induced level induce periodic stratum deformation. Usi...

OBJECTIVE(S) This study was carried out to evaluate the effect of maternal morphine exposure during gestational and lactation period on pyramidal neurons of hippocampus in 18 and 32 day mice offspring. MATERIALS AND METHODS Thirty female mice were randomly allocated into cases and controls. In case group, animals received morphine sulfate 10 mg/kg.body weight intraperitoneally during 7 days b...

Desquamation is described as a protease-dependent phenomenon where serine proteases with a basic pH optimum play a key role. Recently proteases with an acidic pH optimum were identified in the stratumcorneum and associated with desquamation, e.g., cathepsin D and the stratum corneum thiol protease. The purpose of this study was to investigate if human stratum corneum contains proteases differen...

OBJECTIVE To describe inequalities in the infant mortality rate (IMR) according to socioeconomic indicators among geographic areas and municipalities in Brazil. METHODS This was an exploratory ecological study of space aggregates that described IMR in 2006-2008 according to municipalities, states, and the Family Development Index (FDI), a socioeconomic indicator that ranges from 0 to 1. All t...

The age-related changes in the electrical and physiological properties of the skin were examined in rats at the ages of 5, 10, 21, 90, and 180 d. The resistance of the stratum corneum, the resistance of the viable skin (epidermis and dermis), and the capacitance of the stratum corneum were analyzed from skin impedance data using an equivalent circuit. With development and aging, the resistance ...

Two-photon fluorescence lifetime imaging is used to identify microdomains (1-25 microm) of two distinct pH values within the uppermost layer of the epidermis (stratum corneum). The fluorophore used is 2',7'-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein (BCECF), whose lifetime tau (pH 4.5, tau = 2.75 ns; pH 8.5, tau = 3.90 ns) is pH dependent over the pH range of the stratum corneum (pH 4.5 ...

The stratum intermedium develops as flattened cell layer on the proximal side of the ameloblast layer during the bell stage of tooth development. Stratum intermedium cells strongly express alkaline phosphatase (ALP) activity and have been considered to play a complementary role in the enamel mineralization, however the origin and/or the role of these cells have not been elucidated. In the prese...