Proteins possess distinct intracellular roles allowing them to have vast therapeutic applications. However, due to poor cellular permeability and fragility of most proteins, intracellular delivery of native, active proteins is challenging. We describe a biomimetic protein delivery vehicle which is degradable upon the digestion by furin, a ubiquitous intracellular protease, to release encapsulat...

the aim followed in the present research was to study the effects of reduction in dietary crude protein on milk production and on blood components in lactating holstein dairy cows when in heat stress. a number of 63 holstein dairy cows (71 ± 16.5 dim) were chosen to be made use of in a randomized complete block design. the cows were randomly assigned to any one of the three experimental rations...

The objective of this study was to determine the undegradable dietary protein requirements of veal calves. Two experiments were carried out with Holstein bull calves from 3-10 days of age until slaughter at 20 weeks of age. Both experiments were divided into starter and finishing periods. Calves were offered starter pellets on an ad lib. basis from seven days of age. Diets were formulated to be...

Trianthema portulacastrum (common farm weed in tropical countries) contains 21.5 ± 1.2% crude protein, similar to Lucerne with relatively low structural carbohydrate (neutral detergent fibre: 43.6 ± 3.1%). The mineral profile of T. portulacastrum was well above the critical level as far as calcium (0.3%), magnesium (0.2%), iron (50 ppm), copper (8 ppm), zinc (30.0 ppm) and manganese (50 ppm), w...

OBJECTIVE This trial was performed to examine the effects of ruminally degradable starch (RDS) levels in total mixed ration (TMR) with low corn-based starch on the milk production, whole-tract nutrient digestibility and nitrogen balance in dairy cows. METHODS Eight multiparous Holstein cows (body weight [BW]: 717±63 kg; days in milk [DIM]: 169±29) were assigned to a crossover design with two ...

A reactive oxygen species (ROS)-degradable scaffold is fabricated by crosslinking biocompatible, hydrolytically-degradable poly(ε-caprolactone) (PCL) with a ROS-degradable oligoproline peptide, KP7K. The ROS-mediated degradability triggers favorable host responses of the scaffold including improved cell infiltration and angiogenesis in vivo, indicating its unique advantages for tissue engineeri...

protein nutritional status of dairy cows. Milk urea nitrogen reflects the amount of urea found in milk and these values are closely correlated with the concentration of urea found in the blood. MUN values should not be used by themselves when evaluation a herd’s feeding program but can be used in conjunction with evaluating milk production records, feeding management practices, and dry matter, ...