Deoxyribonuclease (DNase) activities have been partially purified from human serum and pancreas. Several of their physical and enzymatic characteristics were determined and compared in order to evaluate their relatedness. Human serum deoxyribonuclease has an isoelectric point in the range of 3.9 to 4.3 and a molecular weight of 33,000 to 38,000. Optimal enzymatic activity at pH 7.0 was dependen...

The source of DNA for Deoxyribonuclease (DNase) producing bacteria in soil is the decaying plant cells, dead animal and bial cells. Very few organisms produce DNase extracellularly. Soil samples from different areas of Akola district (India) were screened for deoxyribonuclease production. Of the 100 soil samples screened; 10 efficient deoxyribonuclease producing bacteria were selected for morph...

It was first observed by Kozloff (1) that the deoxyribonuclease activity of cell-free extracts of Escherichiu coli could be increased by treatment with pancreatic ribonuclease. This stimulation was found to result from the destruction by the ribonuclease of an inhibitory ribonucleic acid. The phenomenon of cellular deoxyribonuclease inhibition is a widespread one, having been observed in yeast ...

The immune response after streptococcal infections of the skin and of the joints was studied in an experimental animal model. Hamsters were challenged intradermally or intra-articularly with different streptococcal serotypes, and antibodies for streptolysin O (ASO), deoxyribonuclease B (anti-deoxyribonuclease B), and group A carbohydrate (anti-group A CHO) were determined. After a single inject...

BACKGROUND Alzheimer's disease is the most common cause of dementia and is characterized by a progressive loss of brain tissue leading to amyloid-β accumulation and severe decline in cognitive function. The cause of Alzheimer's disease is poorly understood, and available treatments are limited in their efficacy, particularly for patients with more severe symptoms. CASE PRESENTATION We report ...

Deoxyribonuclease II (DNase II) is also known as acid deoxyribonuclease because it has optimal activity at the low pH environment of lysosomes where it is typically found in higher eukaryotes. Interestingly, DNase II has also been identified in a few genera of bacteria and is believed to have arisen via horizontal transfer. Here, we demonstrate that recombinant Burkholderia thailandensis DNase ...

Immune status of apparently healthy Nepalese against hemolytic streptococci was studied by measuring antibodies to various streptococcal antigens such as streptolysin-O (SO), streptokinase (SK), deoxyribonuclease-B (DN-B) and streptococcal polysaccharide (SP). The normal range of anti-streptolysin-O (ASO), anti-streptokinase (ASK), anti-deoxyribonuclease-B (ADN-B) and anti-Streptococcus polysac...