Objective(s): Exposing to stress may be associated with increased production of reactive oxygen species (ROS). Therefore, high level of oxidative stress may eventually give rise to accumulation of oxidative damage and development of numerous neurodegenerative diseases. It has been presented that brain-derived neurotrophic factor (BDNF) supports neurons against various neurodegenerative conditio...

PURPOSE A prior study showed that brain-derived neurotrophic factor (BDNF) rescues photoreceptors from collateral retinal damage caused by photodynamic therapy (PDT). This study was conducted to determine whether ciliary neurotrophic factor (CNTF), a combination of BDNF and CNTF, or pigment epithelial cell-derived growth factor (PEDF) might protect photoreceptors and retinal function more effec...

It was hypothesized that mesenchymal stem cells (MSCs) could provide necessary trophic factors when seeded onto the surfaces of commonly used nerve graft substitutes. We aimed to determine gene expression MSCs influenced by Avance® Nerve Grafts or NeuraGen® Guides. Human adipose-derived were cultured and dynamically 30 Guides for 12 hours. At six time points after seeding, quantitative polymera...

Fetal-neonatal iron deficiency alters hippocampal neuronal morphology, reduces its volume, and is associated with acute and long-term learning impairments. However, neither the effects of early-life iron deficiency anemia on growth, differentiation, and survival of hippocampal neurons nor regulation of the neurotrophic factors that mediate these processes has been investigated. We compared hipp...

This research grant will investigate methylation patterns in the brain-derived neurotrophic factor (BDNF) gene. Published research has reported that the BDNF gene and its products have been associated with suicidal behavior. Several lines of evidence point to BDNF as a factor in mood disorders and specifically bipolar disorder illnesses, where there are greater percentages of suicides or attemp...

Objective(s):Theneuroprotective effect of lithium has been attributed to its therapeutic action. However, the role of glial cells particularly astrocytes, and the possible interactions between neurons and astrocytes in neuroprotective effects of lithium have been disregarded. Thus, the aim of this study was to evaluate the direct effects of lithium on brain derived neurotrophic factor (BDNF) an...

background: the induction of brain-derived neurotrophic factor (bdnf) expression in the hippocampus has shown to play a role in the beneficial effects of resveratrol (rsv) on the learning and memory. the bdnf gene has a complicated structure with eight 5’ noncoding exons (i-ixa), each of which can splice to a common coding exon (ix) to form a functional transcript. estrogens increase levels of ...

Depression is a complex psychiatric disorder that significantly impacts millions of individuals worldwide. Despite advances in our understanding its neurobiological underpinnings, treatment options remain limited, and not all patients respond adequately to available therapies. Emerging evidence has implicated brain-derived neurotrophic factor (BDNF), critical regulator neuronal plasticity, the ...

low glucose condition induces neuronal cell-death via intracellular mechanisms including mitogen-activated protein kinases (mapk) signaling pathways. it has been shown that low glucose medium decreases neuronal survival in cerebellar granule neurons (cgns). in this study, we have examined the activation of jnk, p38kinase and erk1/2 pathways in low glucose medium in cgns. the cgns were prepared ...

Abbreviations: GDNF, glial cell line-derived neurotrophic factor; BDNF, brain-derived neurotrophic factor; DA, dopaminergic; 6-OHDA, 6-hydroxydopamine; Ad, adenoviral; SN, substantia nigra pars compacta; CNS, central nervous system; MFB, medial forebrain bundle; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPP+, 1-methyl-4-phenyl pyridinium; MAO-B, monoamine oxidase; TH, tyrosine hydroxy...