BACKGROUND Dermatitis herpetiformis is an autoimmune disease typically characterized by pruritic vesicles located on the extensor surfaces. Classic disease consists of neutrophils in the dermal papillae. Additional histopathologic findings include fibrin deposition and edema within the dermal papillae. Subepidermal vesicles also may be present. Direct immunofluorescence demonstrates granular Ig...

Dermatitis Herpetiformis is a chronic autoimmune blistering skin condition that often associated with gluten-sensitive enteropathy. The primary lesion of DH an erythematous papule, plaque, or, most commonly, vesicle can be pruritic.

DH: dermatitis herpetiformis DIF: direct immunofluorescence INTRODUCTION Dermatitis herpetiformis (DH) is an autoimmune, subepidermal blistering disease associated with gluten sensitivity. It commonly manifests as intensely pruritic papules and vesicles on the extensor surfaces of extremities in a symmetric distribution. Classic histologic findings and data from direct immunofluorescent (DIF) s...

DH: dermatitis herpetiformis DIF: direct immunofluorescence EED: erythema elevatum diutinum INTRODUCTION Dermatitis herpetiformis (DH) is a cutaneous manifestation of gluten intolerance characterized by an intensely pruritic, papulovesicular eruption with a predilection for the extensor extremities, scalp, and buttocks. Because of its variable clinical presentation, DH can be a challenging clin...

Bullous systemic lupus erythematosus is a rare subset of systemic lupus erythematosus that is even rarer in pediatric patients. We report a case of a 12-year-old girl who presented with a vesiculobullous eruption on her face, neck, trunk and genital and oral mucosa, as well as anemia, sterile pyuria, ANA (1:1280, speckled pattern) and positive anti-Sm and anti-RNP. Pathological examination sugg...

Forty two white patients of British or Irish descent with coeliac disease and 28 with dermatitis herpetiformis were typed for class I HLA-A, B, and C, and class II DR and DQ antigens. In coeliac disease there was a significant increase in the frequencies of A1, B8, DR3, DR7, and DQw2 compared with controls but no increase of DR2. In dermatitis herpetiformis there were similarly increased freque...

Dermatitis herpetiformis (DH) is a rare immunobullous disorder of the skin that is associated with gluten hypersensitivity. Subepidermal IgA-type antibody deposition against tissue transglutaminase leads to dense neutrophilic microabscess and eventually into vesicles in dermal papillae, which may occasionally merge into bullae. Being a subepidermal vesiculobullous disorder, DH is frequently ass...