This study structurally estimates a dynamic model of drug development process in pharmaceutical industry, and uses counterfactual experiments to evaluate e¤ects of various policy interventions aimed at increasing the introduction rate of new drugs within a speci…c therapeutic area. Advanced computational methods –such as continuous time and polynomial approximations –overcome the modeling di¢ c...

Situations that present individuals with a conflict between local and global gains often result in a behavioral pattern known as melioration — a preference for immediate rewards over higher long-term gains. Using a variant of a paradigm by Tunney & Shanks (2002), we explored the potential role of feedback as a means to reduce this bias. We hypothesized that frequent and informative feedback abo...

We study the fundamental problem of how devices, operating over a wireless medium, can discover potential communication partners. For the devices, the spectrum is divided into m frequency channels. As multiple devices share these channels, they have to cope with collisions while they are trying to find other devices in the system. Moreover, we assume an adversarial jammer to block some of the a...

The article describes the main pathophysiological mechanisms underlying potential use of antirheumatic therapy in new COVID-19 patients with rheumatic diseases. Also, it summarizes current data on risk and outcome systemic autoimmune To date, there are no large randomized studies drugs diseases setting COVID-19. Besides, is convincing evidence that any disease-modifying drug (conventional synth...

The chapter examines seamless learning, where the aim is to enable a continuous fl ow of meaning-making despite changes in the physical and social context. One way to achieve this is by inducing a fl ow state such that learners are so engaged in a mobile learning activity that they lose awareness of their surroundings. Mobile educational games may be one way to achieve such fl ow, but this is n...