PURPOSE To quantitatively assess retinal thickness by optical coherence tomography (OCT) in normal subjects and patients with diabetes. This study was intended to determine which retinal thickness value measured with OCT best discriminates between diabetic eyes, with and without macular edema. METHODS OCT retinal thickness was measured by a manual technique in a total of 26 healthy volunteers...

Background: Advanced glycation end-products (AGEs) play a critical role in the pathology of diabetic complications. The aim of this study is to examine the immunolocalization of advanced glycation end products (AGE) and receptor for AGE (RAGE) in human diabetic and non-diabetic donor eyes using immunohistochemistry. Materials and Methods: Eight globes were obtained from human postmortem donors:...

PURPOSE Bevacizumab (Avastin) is a monoclonal antibody which targets all isoforms of vascular endothelial growth factor A. Its potent anti-angiogenic effects have been shown to cause regression of neovascularization in proliferative diabetic retinopathy. The aim of this study is to investigate the role of Avastin as an adjunct to vitrectomy in the management of severe diabetic eye disease. ME...

PURPOSE To investigate the impact of diabetic retinopathy on quantitative retinal nerve fiber layer (RNFL) assessment and diagnostic power for glaucoma by scanning laser polarimetry (GDx-VCC) and optical coherence tomography (StratusOCT). METHODS The individual RNFL parameters of GDx and OCT were obtained for 170 eyes (one eye from each of 170 subjects [45 healthy, 47 glaucoma, 40 diabetes, a...

Background/Aims: The Spontaneously Diabetic Torii (SDT) rat develops advanced diabetic retinopathy (DR). The aim of this study was to identify advanced glycation end products (AGEs) related to vascular endothelial growth factor (VEGF) expression, a cause of DR in SDT rats. Methods: One eye was obtained from six SDT rats (blood glucose, >250 mg/dl) and 10 nondiabetic normal SpragueDawley (SD) ra...

BACKGROUND The purpose of this study was to examine neodymium:yttrium-aluminum garnet (Nd:YAG) capsulotomy rates after combined cataract surgery with implantation of a three-piece 4% water content hydrophobic acrylic intraocular lens (X-70, Eternity®) and vitrectomy, and compare diabetic retinopathy with nondiabetic retinopathy. METHODS Nd:YAG capsulotomy rates were evaluated for 72 eyes of 7...

Background To study the interaction between idiopathic macular telangiectasis type 2 (MacTel2) and coexistent diabetic retinopathy (DR) during long term follow up. Methods A retrospective chart review was done for all eyes with MacTel2 and DR with a minimum 2 years follow up. Eyes with other retinal disorders and poor quality imaging were excluded. Data collected included demographics, presen...

Purpose:Substantial evidence indicates that extracellular matrix accumulation in trabecular meshwork (TM) is associated with aqueous outflow resistance. The purpose of this study is to determine whether excess fibronectin (FN) accumulation in TM contributes to outflow resistance by downregulating synthesis of FN overexpression by the TM cells in primary open angle glaucoma. Methods:Cryosections...

PURPOSE To compare the aqueous humor levels of proinflammatory and angiogenic factors of diabetic patients with and without retinopathy. METHODS Aqueous humor was collected at the start of cataract surgery from diabetic subjects and non-diabetic controls. The presence and severity of diabetic retinopathy were graded with fundus examination. Levels of 22 different inflammatory and angiogenic c...