a sodium salt of 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid, is an important non-steroid anti-inflammatory drug used in rheumatology. 1 In this paper we present the crystal structure of diclofenac sodium pentahydrate (C14H10Cl2NO2) – Na + ·5H2O along with its unique sodium distorted linkage, which were recrystallized from a matrix of chitosan and diclofenac sodium. Ethyl acetate was added ...

Toxicity of diclofenac sodium was evaluated in relation to clinical signs, post mortem findings, liver and kidneys functions in broiler chicken model. Broiler birds (35th day) of groups A1, A2, A3 and A4 were injected diclofenac sodium at dose rate of 1.25, 2.5, 5 and 10 mg/kg body weight intramuscularly, respectively for four consecutive days. The birds of group A5 were injected with 0.2 ml/kg...

Effects of amlodipine, lacidipine and nicardipine on acute phase of inflammation in the carregeenan model in intact rats were investigated in this study. In addition, the most effective dose of nicardipine that had the highest anti-inflammatory impact was investigated in carregeenan test in adrenalectomized rats. The effective dose of nicardipine was tested in the chronic phase of inflammation ...

OBJECTIVE To compare the three non-steroidal anti-inflammatory agents (NSAIDs) Diclofenac potassium, Etodolac and Naproxen sodium in relation to pain, swelling and trismus following impacted third molar surgery. STUDY DESIGN The study was a randomized and a double-blinded study which included 42 healthy young individuals with impacted third molars and bone retention. Patients were randomly as...

This study investigated the toxicity of commercial non-steroid anti-inflammatory drug (NSAID) eye solutions against corneal epithelial cells in vitro. The biologic effects of 1/100-, 1/50-, and 1/10-diluted bromfenac sodium, pranoprofen, diclofenac sodium, and the fluorometholone on corneal epithelial cells were evaluated after 1-, 4-, 12-, and 24-hr of exposure compared to corneal epithelial c...

Diclofenac sodium is a very common drug used in medical practice for analgesia and is freely available over the counter without any medical prescription. The drug is also the most commonly used or misused by quacks working all over India. Many case reports have been published on upper limb catastrophe of unintentional intra-arterial injection of barbiturates, thiopental sodium, narcotics, and t...

OBJECTIVE To compare the analgesic efficacy of diclofenac sodium and paracetamol on post adenotonsillectomy postoperative pain and oral intake. METHODS Between January 1999 and July 2000, 80 children aged 3-14 years, underwent tonsillectomy and adenoidectomy for either recurrent tonsillitis or adenotonsillar hypertrophy in Prince Zeid Ben Al-Hussein Hospital and Prince Rashid Ben Al-Hussein H...

1. Abstract: A new, simple, precise, accurate and selective high performance thin-layer chromatographic (HPTLC) method has been developed and validated for the simultaneous determination of Tolperisone hydrochloride and Diclofenac sodium in a tablet dosage form. Chromatographicseparation was carried out on Merck TLC aluminium sheets of silica gel 60F254 using Toluene: Ethyl acetate: Methanol (4...

BACKGROUND AND THE PURPOSE OF THE STUDY Diclofenac sodium is a non-steroidal anti-inflammatory agent with a short biological half-life (1-2 hr) and requires multiple dosing. This research was carried out to develop and optimize diclofenac sodium loaded alginate-PVP K 30 microbeads to eliminate the need for multiple dosing and adverse effects. METHODS Diclofenac sodium loaded alginate-PVP K 30...

This study evaluated whether the administration of a NSAID, sodium diclofenac, can promote alterations in the expression of Fos protein in central amygdala (CEA) and the lateral hypothalamus (LH) after 6 h of experimental tooth movement with a controlled force of 70 g, applied to the superior central incisors of rats. Adult male rats were anesthetized and divided into four groups: Control, no o...