Local authorities spend considerable resources on social care at home for older adults. Given the expected growth in the population of older adults and budget cuts on local government, it is important to find efficient ways of maintaining and improving the quality of life of older adults. The ageing in place literature suggests that policies in other functions of local authorities may have a si...

This paper highlights some of the difficult issues related with validity of data that occur when dealing with results produced by automatic tools for accessibility testing. In particular the paper shows some experimental results collected by repeatedly applying a testing tool to a number of web sites at two time points and by drawing some conclusions about comparisons between web sites and acro...

MOTIVATION Linking genes and functional information to genetic variants identified by association studies remains difficult. Resources containing extensive genomic annotations are available but often not fully utilized due to heterogeneous data formats. To enhance their accessibility, we integrated many annotation datasets into a user-friendly webserver. AVAILABILITY AND IMPLEMENTATION http:/...

Histone deacetylases are important drug targets, which are difficult to characterize due to their poor accessibility. We have developed a miniaturized assay for the multi-site readout of deacetylase activity and profiled the substrate selectivity of HDACs for acetylation sites on histone H4 and tumor suppressor protein p53.

Over the last decades our global society has been highly influenced by automobility planning. Growing mobility has been seen as an indication of a well-functioning transport system and a society with increasing welfare. Excessive mobility can at the same time lead to urban sprawl, longer travel distances and travel times as well as other problems that can be associated with lower welfare. A pla...

conclusions geographic accessibility of pharmacies at night and on holidays has to be addressed by provincial health policymakers. materials and methods the analysis was based on straight-line distance measurements. we considered 150, 300, 450, 600, and 750 m for pedestrians, and 1, 2, and 3 km for driving accessibility as the acceptable distances. we calculated the number and percentage of hou...

BACKGROUND A method to estimate ease of synthesis (synthetic accessibility) of drug-like molecules is needed in many areas of the drug discovery process. The development and validation of such a method that is able to characterize molecule synthetic accessibility as a score between 1 (easy to make) and 10 (very difficult to make) is described in this article. RESULTS The method for estimation...