نتایج جستجو برای: dige

تعداد نتایج: 682  

Journal: :Infection and immunity 2008
M M Nelson A R Jones J C Carmen A P Sinai R Burchmore J M Wastling

To investigate how intracellular parasites manipulate their host cell environment at the molecular level, we undertook a quantitative proteomic study of cells following infection with the apicomplexan parasite Toxoplasma gondii. Using conventional two-dimensional electrophoresis, difference gel electrophoresis (DIGE), and mass spectrometry, we identified host proteins that were consistently mod...

2013
Shiladitya Chattopadhyay Trayambak Basak Mukti Kant Nayak Gourav Bhardwaj Anupam Mukherjee Rahul Bhowmick Shantanu Sengupta Oishee Chakrabarti Nabendu S. Chatterjee Mamta Chawla-Sarkar

Rotavirus (RV) being the major diarrhoegenic virus causes around 527000 children death (<5 years age) worldwide. In cellular environment, viruses constantly adapt and modulate to survive and replicate while the host cell also responds to combat the situation and this results in the differential regulation of cellular proteins. To identify the virus induced differential expression of proteins, 2...

2009
Masayo Yamada Kiyonaga Fujii Koji Koyama Setsuo Hirohashi Tadashi Kondo

To investigate the proteomic background of the carcinogenesis and progression of pancreatic cancer, the protein expression profiles of nine well-characterized pancreatic adenocarcinoma cell lines, whose metastatic potential was previously examined in a mouse xenograft model, and two immortalized pancreatic duct cell lines were examined. Two-dimensional difference gel electrophoresis (2D-DIGE) i...

Journal: :Journal of Proteomics & Bioinformatics 2008

2015
Maggy T. Sikulu James Monkman Keyur A. Dave Marcus L. Hastie Patricia E. Dale Roger L. Kitching Gerry F. Killeen Brian H. Kay Jeffry J. Gorman Leon E. Hugo

This study investigated proteomic changes occurring in Anopheles gambiae and Anopheles stephensi during adult mosquito aging. These changes were evaluated using two-dimensional difference gel electrophoresis (2D-DIGE) and the identities of aging related proteins were determined using capillary high-pressure liquid chromatography (capHPLC) coupled with a linear ion-trap (LTQ)-Orbitrap XL hybrid ...

2016
Rie Satoh Reiko Teshima Kazumi Kitta Gang-Hua Lang Kathleen Schegg Kenneth Blumenthal Leslie Hicks Bénédicte Labory-Carcenac David Rouquié Rod A. Herman Corinne Herouet-Guicheney Gregory S. Ladics Scott McClain Lars K. Poulsen Laura Privalle Jason M. Ward Nancy Doerrer Jean-Baptiste Rascle

In rice, several allergens have been identified such as the non-specific lipid transfer protein-1, the α-amylase/trypsin-inhibitors, the α-globulin, the 33 kDa glyoxalase I (Gly I), the 52-63 kDa globulin, and the granule-bound starch synthetase. The goal of the present study was to define optimal rice extraction and detection methods that would allow a sensitive and reproducible measure of sev...

Journal: :Proteomics 2013
Ilya A Osterman Alexey V Ustinov Denis V Evdokimov Vladimir A Korshun Petr V Sergiev Marina V Serebryakova Irina A Demina Maria A Galyamina Vadim M Govorun Olga A Dontsova

To investigate the dynamic cellular response to a condition change, selective labeling of the nascent proteome is necessary. Here, we report a method combining click chemistry protein labeling with 2D DIGE. To test the relevance of the method, we compared nascent proteomes of actively growing bacterial cells with that of cells exposed to protein synthesis inhibitor, erythromycin. Cells were inc...

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