Abstract The transcription factor NF-κB is composed of a family, which regulates the expression various genes in immune and inflammatory responses. family consists five members: RelA/p65, RelB, c-Rel, p50/p105, p52/p100, control target by binding to regulatory κB sites homo-or heterodimer forms. Unlike widely known RelA, mechanisms related regulation c-Rel less understood. Interleukin 12b(Il12b...

The impact of complex media on the dynamics active swimmers has gained a thriving interest in research community for their prominent applications various fields. This paper investigates effect viscoelasticity and aggregation chemically powered sphere-dimers by using coarse-grained hybrid mesoscopic simulation technique. perform motion virtue concentration gradient around swimmer’s surface, prod...

A theoretical study of the association phenyl and ortho-substituted aryl derivatives lactic acid was carried out. Two variants hydrogen-bonded associates in gas phase were calculated: non-classical, actually found crystals, simulated classical dimers. The energy advantage dimers non-equivalence diastereotopic electron lone pairs at carbonyl oxygen atom shown.

E-cadherin, an adhesive transmembrane protein of epithelial adherens junctions, forms two types of detergent-resistant dimers: adhesive dimers consisting of cadherin molecules derived from two neighboring cells and lateral dimers incorporating cadherins of the same cell. Both dimers depend on the integrity of the same residue, Trp156. While the relative amounts of these complexes are not certai...

We have optimized the lowest energy structures and calculated interaction energies for the H(2)O-H(2)O, H(2)O-H(2)S, H(2)O-NH(3), and H(2)O-PH(3) dimers with the recently developed explicitly correlated CCSD(T)-F12 methods and the associated VXZ-F12 (where X = D,T,Q) basis sets. For a given cardinal number, we find that the results obtained with the CCSD(T)-F12 methods are much closer to the CC...

Recent interest in the application of density functional theory prompted us to test various functionals for the van der Waals interactions in the rare-gas dimers, the alkaline-earth metal dimers, zinc dimer, and zinc-rare-gas dimers. In the present study, we report such tests for 18 DFT functionals, including both some very recent functionals and some well-established older ones. We draw the fo...

Background: Corona virus disease is caused by SARS-CoV-2. This pandemic has affected over 200 countries. Most of the patients are asymptomatic. The usually mild but in approximately 14% it worsens to severe respiratory impairment and admission ICU. Different tests laboratories have been used assess severity prognosis severely sick Covid-19 addition clinical radiological findings. Aim: To study ...

A mixture of nonelongated monomers A and B capable of formation of three kinds of mesogenic dimers AA, BB, and AB is investigated. We show the possibility of a temperature-induced transition from one nematic phase consisting mostly of dimers AB composed of dissimilar monomers to a different nematic phase consisting mostly of dimers AA and BB composed of similar monomers. The binding energy of d...