The B- to Z-DNA transition was very efficiently induced by dinuclear nickel and copper complexes based on the 1,3-bis(1,5,9-triazacyclododecyl) propane ligand but not by the corresponding mononuclear complexes. This dramatically different behaviour is explained by the formation of a macrochelate of the dinuclear complexes to the DNA.

We report the synthesis and activity of new mononuclear and dinuclear gold amide complexes 1-7. The dinuclear complexes 6b and 7 were characterised by single crystal X-ray analysis. We also report solution NMR and freezing point depression experiments to rationalise their behaviour in solution and question the de-ligation process invoked in gold catalysis.

The structure and stability of the adduct formed in the reaction between Auoxo3, a dinuclear gold(iii) compound, and the model protein hen egg white lysozyme (HEWL) are investigated by X-ray crystallography, UV-Vis absorption spectroscopy and circular dichroism (CD). It is found that Auoxo3 breaks down completely, undergoes reduction and produces reactive gold(i) species able to bind the protei...

The structures, relative stabilities, vertical detachment energies and magnetic coupling properties of a series of manganese-based dinuclear superhalogens and their isoelectronic analogues are explored via a combined density functional theory and broken symmetry study. Both the capabilities of various exchange-correlation functionals and basis set effects are investigated. The large magnitudes ...

Exclusive measurements of twoand three-body events were performed for the system Sn+ ' Mo at 19.1 MeV/nucleon. Most ternary events are consistent with sequential processes in which one of the two deep-inelastic fragments fissions. For such events large diA'erences are found between the fission probabilities of projectilelike and targetlike fragments of a given mass, this probability being large...

In an effort to design dinuclear PtII compounds that maintain the target (DNA) binding profile of the trans-oriented dinuclear bifunctional PtII complexes containing aliphatic linker chains but are less susceptible to metabolic decomposition, the new, longchain dinuclear PtII complexes—[{trans-PtCl(dien)}2-μ-(CH2)n] 2+ (n = 7,10,12, dien = diethylenetriamine)—were synthesized. The toxicity of t...

The bacterioferritin (BFR) of Escherichia coli takes up iron in the ferrous form and stores it within its central cavity as a hydrated ferric oxide mineral. The mechanism by which oxidation of iron (II) occurs in BFR is largely unknown, but previous studies indicated that there is ferroxidase activity associated with a site capable of forming a dinuclear-iron centre within each subunit [Le Brun...

The Sn atoms in the dinuclear title compound, [Sn(2)Br(2)(C(7)H(7))(4)(OH)(2)], exist in distorted trigonal-bipyramidal BrSnC(2)O(2) coordination geometries. Each of the two independent dinuclear mol-ecules comprising the asymmetric unit is disposed about a center of inversion. In the crystal, molecules are linked by an O-H⋯ hydrogen bond.

The diastereoselective formation of a meso-dinuclear Ru(ii) complex of a novel bis-bidentate ligand is reported along with its electrochemical and photophysical properties. The design of the ligand, with its parallel coordination vectors, induces a diastereoselectivity of 1 : 13 : 1 [ΛΛ : (ΛΔ or ΔΛ) : ΔΔ] for the dinuclear complex.

The LCuBr-catalyzed C-H imidation of arenes by N-fluorobenzenesulfonimide (NFSI), previously reported by us, utilizes an inexpensive catalyst and is applicable to a broad scope of complex arenes. The computational and experimental study reported here shows that the mechanism of the reaction is comprised of two parts: (1) generation of the active dinuclear CuII-CuII catalyst; and (2) the catalyt...