A simple, rapid and robust high-throughput assay for the quantitative analysis of metformin in plasma from different species using laser diode thermal desorption interfaced with atmospheric chemical pressure ionization tandem mass spectrometry (LDTD-APCI-MSMS) was developed for use in a pharmaceutical discovery environment. In order to minimize sample preparation a generic protein precipitation...

We describe a sensitive and inexpensive vibrometer based on optical feedback by diffuse scattering to a single-mode diode laser. Fluctuations in the diode laser's operating frequency that are due to scattered light from a vibrating surface are used to detect the amplitude and frequency of surface vibrations. An additional physical vibration of the laser provides an absolute amplitude calibratio...

The Delta4 biplanar diode array dosimeter was validated for helical tomotherapy delivery QA. The basic detector characteristics were found to be satisfactory in terms of short-term reproducibility (0.1%), linearity (<0.1%), dose rate dependence (0.4%), and absolute calibration accuracy (0.4% in the center of the phantom compared with the independently calibrated diode). Relative calibration of ...

A radar transceiver operating at 1.56 THz has recently been developed to obtain coherent, fully polarimetric W-band (98 GHz) RCS images of 1:16 scale model targets. The associated optical system operates by scanning a small focused beam of sweptfrequency radiation across a scale model target to resolve individual scattering centers and obtain the scaled RCS values for the centers. Output from a...

We report on kilohertz-repetition-rate flame temperature measurements performed using blue diode lasers. Two-line atomic fluorescence was performed by using diode lasers emitting at around 410 and 451 nm to probe seeded atomic indium. At a repetition rate of 3.5 kHz our technique offers a precision of 1.5% at 2000 K in laminar methane/air flames. The spatial resolution is better than 150 microm...

A new, seven-state switched perturbation twoport (PTP) for vector reflection measurement based on scalar measurement only was designed and realized in microstrip structure using PIN diodes. The structure was experimentally tested by means of vector measurements of different impedances in frequency band with relative bandwidth of 2.5 octaves. Good agreement with data obtained using a precise vec...

An analysis is made of a two-dimensional array of diodes that can be used for measuring dose generated in a plane by a radiation beam. This measuring device is the MapCHECK Model 1175 (Sun Nuclear, Melbourne, FL). This device has 445 N-type diodes in a 22 x 22 cm2 2-D array with variable spacing. The entire array of diodes is easily calibrated to allow for measurements in absolute dose. For IMR...