diosgenin is an important compound in pharmaceutical industry. it has various effects such as hypocholesterolemic action or antioxidant activity in hiv infected patients. biological oxidation pathways are involved in causing or aggravating heart disease. this study investigated the potential protective effect of diosgenin on cell viability and antioxidant defenses of cultured h9c2 cells submitt...

BACKGROUND Diosgenin, a phytosteroid sapogenin, has anti-inflammatory properties shown to reduce myocardial ischemia-reperfusion injury (MIRI). However, the specific mechanism by which this is achieved is not clear. This study investigated the protective effects of diosgenin on myocardial ischemia/reperfusion (I/R) and the potential anti-inflammatory mechanisms. MATERIAL AND METHODS Healthy adu...

In the present study, we have shown for the first time that a plant steroid, diosgenin, causes an inhibition of the growth of fibroblast-like synoviocytes from human rheumatoid arthritis, with apoptosis induction associated with cyclooxygenase-2 (COX-2) up-regulation. Celecoxib, a selective COX-2 inhibitor, provoked a large decrease in diosgenin-induced apoptosis even in the presence of exogeno...

Diosgenin, a steroidal saponin present in fenugreek (Trigonella foenum graecum) and other plants, has been shown to suppress inflammation, inhibit proliferation, and induce apoptosis in a variety of tumor cells, but through a mechanism that is poorly understood. In the present study, we report that diosgenin inhibits receptor-activated nuclear factor-kappaB ligand-induced osteoclastogenesis, su...

Doxorubicin (DOX) induces oxidative stress leading to cardiotoxicity. Diosgenin, a steroidal saponin of Dioscorea opposita, has been reported to have antioxidant activity. Our study was aimed to find out the protective effect of diosgenin against DOX-induced cardiotoxicity in mice. DOX treatment led to a significant decrease in the ratio of heart weight to body weight, and increases in the bloo...

These studies were undertaken to characterize the role of plasma membrane cholesterol in canalicular secretory functions and hepatocyte integrity against intravenous taurocholate administration. Cholesterol and sphingomyelin concentrations and cholesterol/phospholipid ratios were significantly increased in canalicular membranes of diosgenin-fed rats, suggesting a more resistant structure agains...

Gokshur is one of the plant used in Ayurveda.The plant has diuretic activity.Brihat gokshur and Laghu gokshur are the plants used under the mishrak varga Dashmoola. Both the varieties contains sapogenins,tannins,glycoside etc.. chemical constituents. Among these steroidal saponin is the main active principle which is responsible for the diuretic activity of the plant. The present research work ...

Phytochemicals found in foods and spices are progressively gaining popularity over conventional synthetic drugs mainly because they act via multiple molecular targets that synergize to efficiently prevent or treat chronic illnesses. Phytochemicals are also safe (with minimal or no toxic or side effects) with better bioavailability. Food saponins have been used in complimentary and traditional m...

A novel dioscin-glycosidase that specifically hydrolyzes multi-glycosides such as 3-O-alpha-L-(1 --> 4)-rhamnoside, 3-O-alpha-L-(1 --> 2)-rhamnoside, 3-O-alpha-L-(1 --> 4)-arabinoside and beta-D-glucoside on diosgenin was isolated from Absidia sp.d38 strain; and it was purified and characterized. The molecular weight of the new dioscin-glycosidase is about 55 kDa in SDS-PAGE. The the dioscin-gl...

Diosgenin [or (22R,25R)-spirost-5-en-3β-ol] is the starting material of the Marker degradation, a cheap semi-synthesis of progesterone, which has been designated as an Inter-national Historic Chemical Landmark. Thus far, a single X-ray structure for diosgenin is known, namely its dimethyl sulfoxide solvate [Zhang et al. (2005 ▶). Acta Cryst. E61, o2324-o2325]. We have now determined the structu...