OBJECTIVE The authors sought to identify patterns and associations of prescription and over-the-counter sedative-hypnotic use in an older, rural, blue-collar, community-based cohort in southwestern Pennsylvania over 10 years. METHODS A group of 1,627 individuals age 65 and over were recruited and assessed during 1987-1989 and re-assessed during approximately biennial waves. Data included slee...

STUDY OBJECTIVE Intravenous (IV) prochlorperazine with diphenhydramine is superior to subcutaneous sumatriptan in the treatment of migraine patients presenting to the emergency department (ED). METHODS In this randomized, double-blind, placebo-controlled trial, after providing written informed consent, patients presenting to the ED with a chief complaint of migraine received a 500-mL bolus of...

BACKGROUND Sedating antihistamines may impair driving performance as seriously as alcohol. OBJECTIVE To compare the effects of fexofenadine, diphenhydramine, alcohol, and placebo on driving performance. DESIGN Randomized, double-blind, double-dummy, four-treatment, four-period crossover trial. SETTING The Iowa Driving Simulator. PARTICIPANTS 40 licensed drivers with seasonal allergic rh...

diphenhydramine, as an antihistamine drug is widely used for the treatment of allergies. however, being classified as an over the counter medication and the general belief on the low adverse effect profile of this drug has made it widely accessible to the families. recent reports of diphenhydramine intoxication and mortality, noticeably in children and infants have raised some serious concerns....

BACKGROUND Antihistamines are among the most frequently used medications in the United States. Despite dramatically higher cost, second-generation antihistamines are replacing diphenhydramine because of the perception that they are not constrained by its sedating effects. OBJECTIVE We sought to examine, through meta-analytic procedures, the collective evidence regarding the sedating and perfo...

medical devices (urinary catheter or physical restraints), and blinded medical record extractions for diphenhydramine use. Results. Of the 426 patients, 114 (27%) received diphenhydramine during hospitalization and shared similar baseline characteristics including age, sex, delirium risk, and Mini-Mental State Examination scores compared with nonexposed patients. The diphenhydramine-exposed gro...

medical devices (urinary catheter or physical restraints), and blinded medical record extractions for diphenhydramine use. Results. Of the 426 patients, 114 (27%) received diphenhydramine during hospitalization and shared similar baseline characteristics including age, sex, delirium risk, and Mini-Mental State Examination scores compared with nonexposed patients. The diphenhydramine-exposed gro...

To the Editor—Sedation is a common side-effect of drugs used to treat Parkinson's disease, especially anticholinergic and dopaminergic drugs. Caffeine and methylphenidate may alleviate this sedation and improve the treatment of Parkinson's disease. Two case histories provided the initial basis for this idea. The first patient was a healthy adult who occasionally needed diphenhydramine for aller...

PURPOSE In this study the potential of diphenhydramine in reducing respectively preventing vertigo and nausea induced by the ultra-high static magnetic field at 7 T was evaluated. MATERIALS AND METHODS In a prospective, double blinded, placebo controlled, cross-over randomized study the sensations of 34 volunteers before, during and after exposure to the static magnetic field with and without...