purpose: the present study aims at comparing the impact of two teaching/learning approaches-self- directed/paced learning and lecture/demonstration-based instruction-on mastering psychomotor skills among nursing students. material & method: thirty nursing students were selected for the study. they filled out questionnaires indicating the demographic factor, and mean exam scores achieved in the ...

objective(s):multidrug resistance (mdr) of cancer cells is a major obstacle to successful chemotherapy. overexpression of breast cancer resistance protein (bcrp) is one of the major causes of mdr. in addition, it has been shown that pi3k/akt signaling pathway involves in drug resistance. therefore, we evaluated the effects of novel approaches including sirna directed against bcrp and targeted t...

Firefly luciferase, one of the most extensively studied enzymes, has numerous applications. However, luciferase activity is inhibited by sodium chloride. This study was aimed at obtaining mutant enzymes resistant to chloride inhibition. We first obtained two whose inhibition were alleviated and determined mutations be Val288Ile Glu488Val. Under medical dialysis condition (140 mM chloride), wild...

Inhibition of protein synthesis by streptomycin was tested in extracts from a strain of Escherichia coli sensitive to streptomycin. Three kinds of messenger ribonucleic acid (RNA) were employed: endogenous cellular RNA, extracted cellular RNA, and phage R17 RNA. Protein synthesis directed by extracted cellular RNA was inhibited three- to fourfold more than protein synthesis directed by endogeno...