background: angiotensin ii (ang ii) has an important role on cerebral microcirculation however, its direct roles in terms of ischemic brain edema need to be clarified. this study evaluated the role of central ang ii by using candesartan, as an at1 receptor blocker, in the brain edema formation and blood-brain barrier (bbb) disruption caused by ischemia/reperfusion (i/r) injuries in rat. methods...

background: nitric oxide synthase (nos) activity is increased during hypertension and cerebral ischemia. nos inactivation reduces stroke-induced cerebral injuries, but little is known about its role in blood-brain barrier (bbb) disruption and cerebral edema formation during stroke in acute hypertension. here, we investigated the role of nos inhibition in progression of edema formation and bbb d...

in the last two decades due to globalization of supply chain, enormous changes occurred in chains. leaders in this field, always facing new risks and disorders that should prepare themselves to deal with them. in the recent years, sanctions as one of the most serious risks have damaged the supply chains. however, in the research related to global supply chains, modeling of disruption has been n...

major pancreatic injury following blunt abdominal trauma by itself is a relatively rare occurrence, and in vast majority of cases (95%) it is associated with injury to adjacent major vessels and organs; thus making isolated major pancreatic injury even rarer. while most pancreatic injuries are managed by simple measures like debridement and drainage, complex proximal injury poses surgical chall...