Ubiquitin activating enzyme E1 plays a pivotal role in ubiquitin based protein signaling through regulating the initiating step of the cascade. Previous studies demonstrated that E1 is inhibited by covalent modification of reactive cysteines contained within the ubiquitin-binding groove and by conditions that increase oxidative stress and deplete cellular antioxidants. In this study, we determi...

Dithiocarbamates are highly versatile, mono-ionic chelates that form stable complexes with many transition metals and main group elements. Ccmplexes of cobalt(II) piperidine dithiocarbamate and diamines such as Ethylene diamine, Diethylene triamine and Triethylene tetramaine have been synthesised . The complexes have been characterized by IR , UV-Vis and EPR spectral studies , Thermal and magne...

A search of the Cambridge Structural Database was conducted for pyridyl-substituted dithiocarbamate ligands. This entailed molecules containing both an NCS2? residue and pyridyl group(s), in order to study their complexation behavior transition metal main group element crystals, i.e., d- p-block elements. In all, 73 different structures were identified with 30 distinct As a general observation,...

Thirty clinical isolates of Candida albicans and 10 other Candida species were tested for susceptibility to 6 substituted dithiocarbamates and one dimercaptosuccinate. Dimethyldithiocarbamate, sodium pyrrolidine dithiocarbamate, and sodium diethyldithiocarbamate showed dose-dependent antifungal activity which was par­ tially reversed by the addition of zinc, copper, or iron sulfate with greates...

17 β -Hydroxysteroid dehydrogenase type 1 (17 β -HSD1) catalyzes the conversion of estrone to the potent estrogen estradiol. 17 β -HSD1 is highly expressed in breast and ovary tissues and represents a prognostic marker for the tumor progression and survival of patients with breast cancer and other estrogen-dependent tumors. Therefore, the enzyme is considered a promising drug target against est...