DNA based spherical nanostructures are one of the promising nanostructures for several biomedical and biotechnological applications due to their excellent biocompatibility and DNA-directed surface addressability. Herein, we report the synthesis and amphiphilicity-driven self-assembly of two classes of DNA (hydrophilic)-chromophore (hydrophobic) hybrid amphiphiles into spherical nanostructures. ...

Self-assembly is the spontaneous self-ordering of substructures into superstructures, driven by the selective affinity of the substructures. Complementarity of DNA bases renders DNA an ideal material for programmable selfassembly of nanostructures. DNA self-assembly is the most advanced and versatile system that has been experimentally demonstrated for programmable construction of patterned sys...

Background: The effect of subthalamic nucleus deep brain stimulation (STN-DBS) on the voice features in Parkinson’s disease (PD) is controversial. No study has evaluated the voice features of PD underwent STN-DBS by the acoustic, perceptual, and patient-based assessments comprehensively. Furthermore, there is no study to investigate prosodic features before and after DBS in PD. The curren...

We study the times to grow structures within the tile self-assembly model proposed by Winfree, and the possible shapes that can be achieved. Our earlier work was confined to the growth of rectangular structures, in which the rates of attachment of border tiles and rule tiles were the same. By varying the relative rates one can engineer interesting new shapes, which have been observed in the lab...

High speed trains are an indispensable part of rapid transportation systems in many countries. As the fastest means of transport on the ground, these trains are extremely sensitive to the terrain and track conditions. Geometrical irregularities and mechanical characteristics of the track, together with inconsistencies in the lane (including bridges that support the track) are considered importa...

Recent results of corpus-based linguistics demonstrate that context-appropriate sentences can be generated by a stochastic constraint satisfaction process. Exploiting the similarity of constraint satisfaction and DNA self-assembly, we explore a DNA assembly model of sentence generation. The words and phrases in a language corpus are encoded as DNA molecules to build a language model of the corp...

While the topic of Molecular Computation would have appeared even a half dozen years ago to be purely conjectural, it now is an emerging sub eld of computer science with the development of its theoretical basis and a number of moderate to large-scale experimental demonstrations. This paper focuses on a subarea of Molecular Computation known as DNA self-assembly. Self-assembly is the spontaneous...