Abstract The origins of DNA nanotechnology can be traced back to 1982, when Dr. Ned Seeman proposed assembling branched junctions as 3D lattices facilitate protein crystallization. Over the past four decades, this concept has evolved into a multidisciplinary research field with vast potential for applications. In mini review, we present brief introduction selected topics in nucleic acid nanotec...

We report that double-helical DNA constraints can be used to control the conformation of another molecule, RNA. When a covalently attached DNA constraint is structurally incompatible with the native Mg2+-dependent RNA conformation, RNA folding is disrupted, as revealed by nondenaturing gel electrophoresis and independently by chemical probing. Our approach is distinct from other efforts in DNA ...

DNA’s molecular recognition properties have made it one of the most widely used biomacromolecular construction materials. The programmed assembly of DNA oligonucleotides has been used to create complex 2D and 3D self-assembled architectures and to guide the assembly of other molecules. The origins of DNA nanotechnology are rooted in the goal of assembling DNA molecules into designed periodic ar...