Abstract Chromosomal instability (CIN) is a hallmark of cancer and contributes to tumorigenesis tumor progression. While structural CIN (S-CIN) leads chromosome aberrations, whole (W-CIN) defined by perpetual gains or losses chromosomes during mitosis causing aneuploidy. Mitotic defects, but also abnormal DNA replication (replication stress) can lead W-CIN. However, the functional link between ...

Geminivirus replication initiator protein (Rep) is a multifunctional viral required for replication. During the process of replication, Rep acts as site- and strand-specific endonuclease, ligase, ATPase, helicase. B' motif β-hairpin loop geminivirus are conserved important Rep-mediated helicase activity To dissect roles various amino acid residues in its unwinding DNA, we investigated eight nea...